反应条件
1: 86 percent / 2 N NaOH / dioxane; H2O / 0.5 h / 0 - 5 °C
2: 99 percent / SOCl2 / benzene / 2 h / Heating
3: 2.) (i-Pr)2NEt / 1.) CH2Cl2, 25 deg C, 2.) CH2Cl2, 25 deg C, 64 h
4: HBr
5: Et3N / N,N-dimethyl-acetamide / 120 h / 25 °C
View Scheme
参考文献
Piper; Montgomery; Sirotnak; Chello
Journal of Medicinal Chemistry, 1982 , vol. 25, # 2 p. 182 - 187
