反应条件
1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 48 h / Reflux 2.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 1 h / 0 °C 2.2: 1 h / -78 - 20 °C 3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 0 °C View Scheme
参考文献
Gillespie, Roger J.; Bamford, Samantha J.; Botting, Ruth; Comer, Mike; Denny, Sarah; Gaur, Suneel; Griffin, Michael; Jordan, Allan M.; Knight, Anthony R.; Lerpiniere, Joanne; Leonardi, Stefania; Lightowler, Sean; McAteer, Steven; Merrett, Angela; Misra, Anil; Padfield, Antony; Reece, Mark; Saadi, Mona; Selwood, Daniel L.; Stratton, Gemma C.; Surry, Dominic; Todd, Richard; Tong, Xin; Ruston, Vicki; Upton, Rebecca; Weiss, Scott M.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 1 p. 33 - 47