3α-羟基-7-氧代-胆烷酸-24-甲酯合成路线 （共 8 条）
反应条件
1: Et3N, N,N-dimethylaminopyridine 2: 80 percent / BF3*Et2O / acetic acid / 5 h / 55 °C 3: 93 percent / NaBH4, MeOH / CH2Cl2 / 0.25 h / Ambient temperature 4: 82 percent / 2M methanolic KOH / Heating View Scheme
参考文献
Hsia et al.
Journal of Biological Chemistry, 1957 , vol. 225, p. 811,818
Journal of Biological Chemistry, 1958 , vol. 233, p. 1337
反应条件
1: pyridine 2: bromine; HBr; acetic acid 3: aqueous methanol. KOH / 20 °C 4: boron fluoride ether adduct 5: Raney nickel; aqueous ethanol View Scheme
参考文献
Hsia et al.
Journal of Biological Chemistry, 1957 , vol. 225, p. 811,818
Journal of Biological Chemistry, 1958 , vol. 233, p. 1337
反应条件
potassium tri-sec-butyl-borohydride T=-45°C; 5 h;
参考文献
Tal, Daniel M.; Frisch, G. Douglas; Elliott, William H.
Tetrahedron, 1984 , vol. 40, # 5 p. 851 - 854
反应条件
tert-butylamine borane in methanol 3 h; Ambient temperature; Yield given. Yields of byproduct given;
参考文献
Chang, Frederic C.
Synthetic Communications, 1981 , vol. 11, # 11 p. 875 - 880
反应条件
in diethyl ether 2 h; Ambient temperature;
参考文献
Une, Mizohu; Yamanaga, Katsumi; Mosbach, Erwin H.; Kuroki, Syoji; Hoshita, Takahiko
Steroids, 1989 , vol. 53, # 1-2 p. 97 - 106
反应条件
tert-butylamine borane in methanol 3 h; Ambient temperature; Yield given. Yields of byproduct given;
参考文献
Synthetic Communications, , vol. 11, # 11 p. 875 - 880
反应条件
Multi-step reaction with 2 steps 1: pyridine2: bromine; HBr; acetic acid
参考文献
Hsia et al. Journal of Biological Chemistry, 1957 , vol. 225, p. 811,818Journal of Biological Chemistry, 1958 , vol. 233, p. 1337
反应条件
Multi-step reaction with 2 steps 1: Et3N, N,N-dimethylaminopyridine2: 80 percent / BF3*Et2O / acetic acid / 5 h / 55 °C
参考文献
Yoshimura, Teruki; Mahara, Reijiro; Kurosawa, Takao; Ikegawa, Shigeo; Tohma, Masahiko Steroids, 1993 , vol. 58, # 2 p. 52 - 58
