5-{4-[2-(5-乙基-2-吡啶基)-乙氧基]-苄基}-2-亚氨基-4-噻唑烷酮合成路线 （共 12 条）
反应条件
sodium acetate in isopropyl alcohol T=20 - 85°C; 6 h;
参考文献
MOREPEN LABORATORIES LIMITED
Patent: WO2006/35459 A1, 2006 ;
Location in patent: Page/Page column 24; 25 ;
反应条件
in dimethyl sulfoxide T=30 - 70°C; 8 h;
参考文献
WO2004/108721 A1, ;
Page 11-12 ;
反应条件
1: With sodium acetate; potassium iodide in methanol 24 h; RefluxIndustry scale; 2: With potassium carbonate in water; ethyl acetate 0.5 h; RefluxIndustry scale;
参考文献
WO2009/133576 A1, ;
Page/Page column 7 ;
反应条件
sodium tetrahydroborate; cobalt(II) chloride in tetrahydrofuran; methanol; Dimethylglyoxime; water T=15 - 20°C; 10 h; Product distribution / selectivity;
参考文献
WO2008/75380 A2, ;
Page/Page column 15 ;
反应条件
sodium tetrahydroborate; cobalt(II) chloride in tetrahydrofuran; methanol; Dimethylglyoxime; water T=15 - 20°C; 10 h; Product distribution / selectivity;
参考文献
WO2008/75380 A2, ;
Page/Page column 16 ;
反应条件
sodium acetate in ethanol Heating;
参考文献
Sohda; Momose; Meguro; Kawamatsu; Sugiyama; Ikeda
Arzneimittel-Forschung/Drug Research, 1990 , vol. 40, # 1 p. 37 - 42
反应条件
1: 63 percent / NaH / dimethylformamide 2: H2 / 10percent Pd-C / methanol / 760 Torr / Ambient temperature 3: 1.)47percent HBr, NaNO2, 2.)Cu2O / 1.)MeOH, H2O, 5 deg C, 20 min., 2.)40 deg C 4: 53 percent / NaOAc / ethanol / Heating View Scheme
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 40, # 1 p. 37 - 42
反应条件
1: H2 / 10percent Pd-C / methanol / 760 Torr / Ambient temperature 2: 1.)47percent HBr, NaNO2, 2.)Cu2O / 1.)MeOH, H2O, 5 deg C, 20 min., 2.)40 deg C 3: 53 percent / NaOAc / ethanol / Heating View Scheme
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 40, # 1 p. 37 - 42
反应条件
1: 63 percent / NaH / dimethylformamide 2: H2 / 10percent Pd-C / methanol / 760 Torr / Ambient temperature 3: 1.)47percent HBr, NaNO2, 2.)Cu2O / 1.)MeOH, H2O, 5 deg C, 20 min., 2.)40 deg C 4: 53 percent / NaOAc / ethanol / Heating View Scheme
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 40, # 1 p. 37 - 42
反应条件
1: 1.)47percent HBr, NaNO2, 2.)Cu2O / 1.)MeOH, H2O, 5 deg C, 20 min., 2.)40 deg C 2: 53 percent / NaOAc / ethanol / Heating View Scheme
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 40, # 1 p. 37 - 42
