甲基-2-溴代-3-{4-[2-(5-乙基-2-吡啶基)乙氧基]苯基}丙酸合成路线 （共 11 条）
反应条件
1: With hydrogen bromide in methanol; water; acetone T=10 - 30°C; 0.5 h; 2: With copper(I) oxide; sodium nitrite in methanol; water; acetone T=0 - 42°C; 2.75 h;
参考文献
WO2006/117654 A1, ;
Page/Page column 9-14 ;
反应条件
1: 63 percent / NaH / dimethylformamide 2: H2 / 10percent Pd-C / methanol / 760 Torr / Ambient temperature 3: 1.)47percent HBr, NaNO2, 2.)Cu2O / 1.)MeOH, H2O, 5 deg C, 20 min., 2.)40 deg C View Scheme
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 40, # 1 p. 37 - 42
反应条件
1: H2 / 10percent Pd-C / methanol / 760 Torr / Ambient temperature 2: 1.)47percent HBr, NaNO2, 2.)Cu2O / 1.)MeOH, H2O, 5 deg C, 20 min., 2.)40 deg C View Scheme
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 40, # 1 p. 37 - 42
反应条件
1: 63 percent / NaH / dimethylformamide 2: H2 / 10percent Pd-C / methanol / 760 Torr / Ambient temperature 3: 1.)47percent HBr, NaNO2, 2.)Cu2O / 1.)MeOH, H2O, 5 deg C, 20 min., 2.)40 deg C View Scheme
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 40, # 1 p. 37 - 42
反应条件
copper(I) oxide; hydrogen bromide; sodium nitrite 1.)MeOH, H2O, 5 deg C, 20 min., 2.)40 deg C; Yield given. Multistep reaction;
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 40, # 1 p. 37 - 42
参考文献
Organic Process Research and Development, , vol. 13, # 6 p. 1190 - 1194
反应条件
sodium acetate in ethanol Heating;
参考文献
Sohda; Momose; Meguro; Kawamatsu; Sugiyama; Ikeda
Arzneimittel-Forschung/Drug Research, 1990 , vol. 40, # 1 p. 37 - 42
反应条件
1: 53 percent / NaOAc / ethanol / Heating 2: 2N HCl / 6 h / Heating 3: 12.2 g / 11percent ethanolic HCl / 1 h / Ambient temperature View Scheme
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 40, # 1 p. 37 - 42
反应条件
1: 53 percent / NaOAc / ethanol / Heating 2: 2N HCl / 6 h / Heating View Scheme
参考文献
Sohda; Momose; Meguro; Kawamatsu; Sugiyama; Ikeda
Arzneimittel-Forschung/Drug Research, 1990 , vol. 40, # 1 p. 37 - 42
反应条件
1: With sodium acetate 2: With hydrogenchloride in water
参考文献
Madivada, Lokeswara Rao; Anumala, Raghupathi Reddy; Gilla, Goverdhan; Alla, Sampath; Charagondla, Kavitha; Kagga, Mukkanti; Bhattacharya, Apurba; Bandichhor, Rakeshwar
Organic Process Research and Development, 2009 , vol. 13, # 6 p. 1190 - 1194
