1-二苯基甲基-4-(2-羟基乙基)哌嗪合成路线 （共 12 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide; toluene T=20°C; Reflux;
参考文献
CIPLA LIMITED
Patent: US2012/232091 A1, 2012 ;
Location in patent: Page/Page column 5 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=60°C;
参考文献
Kobayashi; Inoue; Nishino; Fujihara; Oizumi; Kimura
Chemical and Pharmaceutical Bulletin, 1995 , vol. 43, # 5 p. 797 - 817
反应条件
1: N-(2-hydroxy-ethyl)-piperazine With potassium carbonate; potassium iodide in N,N-dimethyl-formamide T=20°C; 2: 1-chloro-1,1-diphenylmethane in N,N-dimethyl-formamide T=20 - 70°C;
参考文献
Burgess, Steven J.; Kelly, Jane X.; Shomloo, Shawheen; Wittlin, Sergio; Brun, Reto; Liebmann, Katherine; Peyton, David H.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 17 p. 6477 - 6489
反应条件
in N,N-dimethyl-formamide
参考文献
Takeda Chemical Industries, Ltd.
Patent: US4603135 A1, 1986 ;
反应条件
4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide in toluene T=20 - 75°C; 2 h;
参考文献
CIPLA LIMITED
Patent: US2012/232091 A1, 2012 ;
Location in patent: Page/Page column 5-6 ;
反应条件
1: 739.8 g / 2 h / 70 - 80 °C 2: piperidine / benzene / 5 h / Heating 3: propan-2-ol / 7 h / Heating View Scheme
参考文献
Meguro; Aizawa; Sohda; Kawamatsu; Nagaoka
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 9 p. 3787 - 3797
反应条件
1: 739.8 g / 2 h / 70 - 80 °C 2: 20 percent NH3/EtOH 3: 17.8 percent / propan-2-ol / 6 h / Heating View Scheme
参考文献
Meguro; Aizawa; Sohda; Kawamatsu; Nagaoka
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 9 p. 3787 - 3797
反应条件
1: 739.8 g / 2 h / 70 - 80 °C 2: 20 percent NH3/EtOH 3: 17.8 percent / propan-2-ol / 6 h / Heating 4: 90.1 percent / 2 N HNO3 / dioxane / 1.5 h / 70 °C View Scheme
参考文献
Meguro; Aizawa; Sohda; Kawamatsu; Nagaoka
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 9 p. 3787 - 3797
反应条件
1: 739.8 g / 2 h / 70 - 80 °C 2: 20 percent NH3/EtOH 3: 17.8 percent / propan-2-ol / 6 h / Heating View Scheme
参考文献
Meguro; Aizawa; Sohda; Kawamatsu; Nagaoka
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 9 p. 3787 - 3797
反应条件
triethylamine in chloroform
10 h; Ambient temperature;
参考文献
Kobayashi; Inoue; Nishino; Fujihara; Oizumi; Kimura
Chemical and Pharmaceutical Bulletin, 1995 , vol. 43, # 5 p. 797 - 817
