N-(8-羟辛基)邻苯二甲酰亚胺合成路线 （共 10 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=60°C; 18 h;
参考文献
Fletcher, David I.; Ganellin, C. Robin; Piergentili, Alessandro; Dunn, Philip M.; Jenkinson, Donald H.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 16 p. 5457 - 5479
反应条件
in N,N-dimethyl-formamide T=90°C; Alkylation; 0.5 h;
参考文献
Zhao, Yongxin; Sinnott, Michael L.
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 5 p. 917 - 924
反应条件
acetic acid T=80°C; 3 h;
参考文献
Sugawara, Tamio; Susaki, Hiroshi; Nogusa, Hideo; Gonsho, Akinori; Iwasawa, Hiroyuki; et al.
Carbohydrate Research, 1993 , vol. 238, # 1 p. 163 - 184
反应条件
1: phthalimide With sodium hydride in DMF (N,N-dimethyl-formamide) T=20°C; 1 h; 2: 1-bromo-octan-8-ol in DMF (N,N-dimethyl-formamide) T=20°C; 3 h;
参考文献
SCHERING AKTIENGESELLSCHAFT
Patent: WO2004/99188 A1, 2004 ;
Location in patent: Page/Page column 29-30 ;
反应条件
1: diethyl azodicarboxylate (DEAD), Ph3P / tetrahydrofuran / 4 h / Ambient temperature 2: 65 percent / 80percent acetic acid / 3 h / 80 °C View Scheme
参考文献
Sugawara, Tamio; Susaki, Hiroshi; Nogusa, Hideo; Gonsho, Akinori; Iwasawa, Hiroyuki; et al.
Carbohydrate Research, 1993 , vol. 238, # 1 p. 163 - 184
反应条件
1: 41 percent / conc. HCl / 1,2-dimethoxy-ethane / 2 h / Ambient temperature 2: diethyl azodicarboxylate (DEAD), Ph3P / tetrahydrofuran / 4 h / Ambient temperature 3: 65 percent / 80percent acetic acid / 3 h / 80 °C View Scheme
参考文献
Sugawara, Tamio; Susaki, Hiroshi; Nogusa, Hideo; Gonsho, Akinori; Iwasawa, Hiroyuki; et al.
Carbohydrate Research, 1993 , vol. 238, # 1 p. 163 - 184
反应条件
in N,N-dimethyl-formamide Reflux;
参考文献
Bartholomae, Mark D.; Vortherms, Anthony R.; Hillier, Shawn; Ploier, Birgit; Joyal, John; Babich, John; Doyle, Robert P.; Zubieta, Jon
ChemMedChem, 2010 , vol. 5, # 9 p. 1513 - 1529
反应条件
in N,N-dimethyl-formamide Reflux;
参考文献
Bartholomae, Mark D.; Vortherms, Anthony R.; Hillier, Shawn; Joyal, John; Babich, John; Doyle, Robert P.; Zubieta, Jon
Dalton Transactions, 2011 , vol. 40, # 23 p. 6216 - 6225
反应条件
hydrazine hydrate in ethanol T=20°C; 18 h;
参考文献
Fletcher, David I.; Ganellin, C. Robin; Piergentili, Alessandro; Dunn, Philip M.; Jenkinson, Donald H.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 16 p. 5457 - 5479
反应条件
carbon tetrabromide; triphenylphosphine in acetonitrile T=20°C; 2.5 h;
参考文献
WO2010/142735 A1, ;
Page/Page column 31; 35 ;
WO 2010/142735 A1
