1-苄氧羰基氮杂环丁烷-3-酮合成路线 （共 10 条）
反应条件
Dess-Martin periodane in dichloromethane T=20°C; 5 h;
参考文献
EXELIXIS, INC.
Patent: WO2008/124085 A2, 2008 ;
Location in patent: Page/Page column 179 ;
WO 2008/124085 A2
参考文献
Nitta, Yoshihiro; Yamaguchi, Tamie; Tanaka, Toshiko
Heterocycles, 1986 , vol. 24, # 1 p. 25 - 28
反应条件
copper acetylacetonate in benzene Cyclization; 1.5 h; Heating;
参考文献
Wang, Jianbo; Hou, Yihua; Wu, Peng
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 16 p. 2277 - 2280
反应条件
1: triethylamine / tetrahydrofuran / 0.5 h / 0 °C 2: 3.32 g / diethyl ether; tetrahydrofuran / 4 h / 0 °C 3: 28 percent / rhodium(II) acetate dimer / CH2Cl2 / 3 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 67, # 5 p. 1536 - 1547
反应条件
1: 3.32 g / diethyl ether; tetrahydrofuran / 4 h / 0 °C 2: 28 percent / rhodium(II) acetate dimer / CH2Cl2 / 3 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 67, # 5 p. 1536 - 1547
反应条件
1: triethylamine / tetrahydrofuran / 60.5 h / 0 - 20 °C / |Inert atmosphere 2: triethylamine; pyridine-SO3 complex / dimethyl sulfoxide / 16.33 h / 0 - 20 °C View Scheme
反应条件
1: Methyltriphenylphosphonium bromide With potassium tert-butylate in diethyl ether
T=20 - 35°C; 1.33333 h;
2: N-(Benzyloxycarbonyl)azetidin-3-one in diethyl ether
T=35°C; 12 h;
参考文献
EXELIXIS, INC.
Patent: WO2008/124085 A2, 2008 ;
Location in patent: Page/Page column 179-180 ;
WO 2008/124085 A2
反应条件
1: Methyltriphenylphosphonium bromide With potassium tert-butylate in diethyl ether
T=20 - 35°C; 1.33333 h;
2: N-(Benzyloxycarbonyl)azetidin-3-one in diethyl ether
T=35°C; 12 h;
参考文献
EXELIXIS, INC.
Patent: WO2007/44515 A1, 2007 ;
Location in patent: Page/Page column 165-166 ;
WO 2007/044515 A1
反应条件
N,N,N',N,-tetramethylethylenediamine; iso-butyllithium in diethyl ether; cyclohexane
T=-78 - 20°C;
参考文献
EXELIXIS, INC.
Patent: WO2008/124085 A2, 2008 ;
Location in patent: Page/Page column 182 ;
WO 2008/124085 A2
反应条件
1: 1-(tert-butoxy-carbonyl)piperidine With N,N,N',N,-tetramethylethylenediamine; iso-butyllithium in diethyl ether; cyclohexane
T=-78°C;
2: N-(Benzyloxycarbonyl)azetidin-3-one in diethyl ether; cyclohexane
T=-60 - 20°C;
参考文献
EXELIXIS, INC.
Patent: WO2007/44515 A1, 2007 ;
Location in patent: Page/Page column 168 ;
WO 2007/044515 A1
