3-羟基-N-[苄氧羰基]-O-(苄基)-L-酪氨酸甲酯合成路线 （共 15 条）
反应条件
1: 61 percent / K2CO3 / dimethylformamide / 6 h / 25 °C 2: H2 / Pd/C / CH2Cl2 3: aq. Na2CO3 / acetonitrile View Scheme
参考文献
Song, Yan-Li; Peach, Megan L.; Roller, Peter P.; Qiu, Su; Wang, Shaomeng; Long, Ya-Qiu
Journal of Medicinal Chemistry, 2006 , vol. 49, # 5 p. 1585 - 1596
反应条件
hydrogen; palladium on activated charcoal in dichloromethane
参考文献
Song, Yan-Li; Peach, Megan L.; Roller, Peter P.; Qiu, Su; Wang, Shaomeng; Long, Ya-Qiu
Journal of Medicinal Chemistry, 2006 , vol. 49, # 5 p. 1585 - 1596
反应条件
dihydrogen peroxide; toluene-4-sulfonic acid in tetrahydrofuran
T=23°C; 24 h;
参考文献
Boger, Dale L.; Yohannes, Daniel
Journal of Organic Chemistry, 1987 , vol. 52, # 23 p. 5283 - 5286
反应条件
1: With 3-chloro-benzenecarboperoxoic acid in dichloromethane
T=20°C; Baeyer-Villiger oxidation; 7 h;
2: With ammonia in methanol
T=20°C; 0.5 h;
参考文献
Morera; Ortar
Synthetic Communications, 2001 , vol. 31, # 14 p. 2215 - 2222
反应条件
dihydrogen peroxide in methanol; water
T=20°C; 0.5 h;
参考文献
Hunter, Luke; Hutton, Craig A.
Australian Journal of Chemistry, 2003 , vol. 56, # 11 p. 1095 - 1098
反应条件
1: SOCl2 / 18 h / 20 °C
2: 6.92 g / Na2CO3 / methanol; toluene / 2 h / 0 °C
3: 96 percent / K2CO3; Cs2CO3 / dimethylformamide / 2 h / 20 °C
4: 88 percent / Pd(dppf)Cl2*CH2Cl2; KOAc / dimethylsulfoxide / 24 h / 80 °C
5: 93 percent / H2O2 / methanol; H2O / 0.5 h / 20 °C
View Scheme
参考文献
Hunter, Luke; Hutton, Craig A.
Australian Journal of Chemistry, 2003 , vol. 56, # 11 p. 1095 - 1098
反应条件
1: 6.92 g / Na2CO3 / methanol; toluene / 2 h / 0 °C
2: 96 percent / K2CO3; Cs2CO3 / dimethylformamide / 2 h / 20 °C
3: 88 percent / Pd(dppf)Cl2*CH2Cl2; KOAc / dimethylsulfoxide / 24 h / 80 °C
4: 93 percent / H2O2 / methanol; H2O / 0.5 h / 20 °C
View Scheme
参考文献
Hunter, Luke; Hutton, Craig A.
Australian Journal of Chemistry, 2003 , vol. 56, # 11 p. 1095 - 1098
反应条件
1: 96 percent / K2CO3; Cs2CO3 / dimethylformamide / 2 h / 20 °C
2: 88 percent / Pd(dppf)Cl2*CH2Cl2; KOAc / dimethylsulfoxide / 24 h / 80 °C
3: 93 percent / H2O2 / methanol; H2O / 0.5 h / 20 °C
View Scheme
参考文献
Hunter, Luke; Hutton, Craig A.
Australian Journal of Chemistry, 2003 , vol. 56, # 11 p. 1095 - 1098
反应条件
1: 60 percent / K2CO3; (n-Bu)4NI / dimethylformamide / 6 h / 20 °C
2: mCPBA / CH2Cl2 / 40 °C
3: 453 mg / NH3 / CH2Cl2; methanol / 1 h
View Scheme
参考文献
Song, Yan-Li; Peach, Megan L.; Roller, Peter P.; Qiu, Su; Wang, Shaomeng; Long, Ya-Qiu
Journal of Medicinal Chemistry, 2006 , vol. 49, # 5 p. 1585 - 1596
反应条件
1: 74 percent / SOCl2 / Heating
2: 93 percent / aq. Na2CO3 / diethyl ether / 3 h / 25 °C
3: 60 percent / K2CO3; (n-Bu)4NI / dimethylformamide / 6 h / 20 °C
4: mCPBA / CH2Cl2 / 40 °C
5: 453 mg / NH3 / CH2Cl2; methanol / 1 h
View Scheme
参考文献
Song, Yan-Li; Peach, Megan L.; Roller, Peter P.; Qiu, Su; Wang, Shaomeng; Long, Ya-Qiu
Journal of Medicinal Chemistry, 2006 , vol. 49, # 5 p. 1585 - 1596
