2-(2-氰基苯基)苯乙酮合成路线 （共 9 条）
反应条件
sodium hydride in ethylene glycol dimethyl ether; mineral oil 20 h; Reflux;
参考文献
WO2011/38204 A1, ;
Page/Page column 145-146 ;
WO 2011/038204 A1
反应条件
sodium hydride in ethylene glycol dimethyl ether 20 h; Heating;
参考文献
Journal of Heterocyclic Chemistry, , vol. 31, # 4 p. 1085 - 1088
反应条件
2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; trimethylsilylazide; oxygen in acetonitrile T=80°C; P=760.051 Torr; 24 h; Schlenk technique; regioselective reaction;
参考文献
Journal of the American Chemical Society, , vol. 135, # 32 p. 11692 - 11695
反应条件
1: 2-methylbenzonitrile With N,N'-dimethyl-N,N'-propyleneurea; lithium diisopropyl amide in tetrahydrofuran; hexane T=-78°C; Metallation; 0.25 h; 2: N-Methoxy-N-methyl-benzamide in tetrahydrofuran; hexane T=-78°C; Acylation; 0.5 h;
参考文献
Organic Preparations and Procedures International, , vol. 31, # 4 p. 407 - 412
反应条件
1: PCl5 / anschliessendes Behandeln mit NH3 in Benzol 2: Behandeln des Reaktionsprodukts mit wss. NaOH View Scheme
参考文献
Gazzetta Chimica Italiana, , vol. 87, p. 707,717
Tetrahedron, , vol. 4, p. 393,400
反应条件
Behandeln des Reaktionsprodukts mit wss. NaOH;
参考文献
Gazzetta Chimica Italiana, , vol. 87, p. 707,717
Tetrahedron, , vol. 4, p. 393,400
反应条件
Friedel-Crafts conditions;
参考文献
Journal of Chemical Research, Miniprint, , # 11 p. 2747 - 2763
反应条件
1: 55 percent / p-toluenesulfonic acid / benzene / 24 h / Heating
2: 62 percent / diborane / tetrahydrofuran / 48 h / 25 °C
3: 28 percent / conc. HCl / methanol; H2O / 0.17 h / Heating
View Scheme
参考文献
Sard, Howard
Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 4 p. 1085 - 1088
反应条件
1: 55 percent / p-toluenesulfonic acid / benzene / 24 h / Heating
2: 62 percent / diborane / tetrahydrofuran / 48 h / 25 °C
3: 50 percent / conc. HCl / methanol; H2O / 0.17 h / Heating
View Scheme
参考文献
Sard, Howard
Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 4 p. 1085 - 1088
