3-(3-甲氧基苯基)丙酸合成路线 （共 43 条）
反应条件
1: ethanol; toluene; sulfuric acid
2: sodium; ethanol / 160 - 170 °C
3: N.N-dimethyl-aniline; chloroform; SOCl2
4: acetone; NaI
5: aqueous ethanol
6: aqueous methanol. KOH-solution
7: thionyl chloride / Reaktion ueber mehrere Stufen
8: diethyl ether; sodium ethylate
View Scheme
参考文献
Robinson; Schlittler
Journal of the Chemical Society, 1935 , p. 1288,1289
反应条件
1: polyphosphoric acid / 4 h / 80 °C / |Inert atmosphere
2: hydrogen bromide; acetic acid / water / 2 h / 110 °C / |Inert atmosphere
3: potassium carbonate / acetone / 5 h / |Reflux; |Inert atmosphere
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参考文献
Nagarapu, Lingaiah; Vulupala, Hanmanth Reddy; Bantu, Rajashaker; Sajja, Yashodakrishna; Nanubolu, Jagadeesh Babu
Tetrahedron Asymmetry, 2014 , vol. 25, # 6-7 p. 578 - 582
反应条件
1: 91 percent / bromine / CH2Cl2 / 0.25 h / 0 °C
2: 66 percent / polyphosphoric acid / 1 h / 60 °C
View Scheme
参考文献
Barnes; Kraft; Gordon
Journal of the American Chemical Society, 1949 , vol. 71, p. 3523,3527
