3-(3-甲氧基苯基)丙酸合成路线 （共 43 条）
反应条件
1: SOCl2
2: NaN3 / acetone; H2O
3: benzene / Heating
4: 35 mg / H3PO4 / CH2Cl2 / 2 h / Ambient temperature
View Scheme
参考文献
Umezawa; Hoshino; Sawaki; Mori
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 3 p. 1003 - 1005
反应条件
bromine in dichloromethane
T=0°C; 0.25 h;
参考文献
Meyer; DeBernardis; Hancock
Journal of Medicinal Chemistry, 1994 , vol. 37, # 1 p. 105 - 112
反应条件
1: 96 percent / LiAlH4 / tetrahydrofuran / brisk reflux, 40 min, reflux, 15 h
2: 77 percent / tetrabromomethane, triphenylphosphine / diethyl ether / reflux, 1 h, 2 h, 15 h
View Scheme
参考文献
Douglas,G.H. et al.
Journal of the Chemical Society, 1963 , p. 5072 - 5094
反应条件
1: β-(3-methoxyphenyl)propionic acid With thionyl chloride in toluene
2 h; Reflux;
2: (S)-(-)-4-benzyl-2-oxazolidinone With n-butyllithium in tetrahydrofuran; hexane; toluene
T=-78°C; 4 h;
参考文献
Millennium Pharmaceuticals, Inc.
Patent: US2012/15942 A1, 2012 ;
Location in patent: Page/Page column 52 ;
US 20120015942 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=50°C; 2 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2009/56886 A1, 2009 ;
Location in patent: Page/Page column 44 ;
WO 2009/056886 A1
反应条件
sulfuric acid
1 h; RefluxInert atmosphere;
参考文献
Thuaud, Frederic; Kojima, Shuntaro; Hirai, Go; Oonuma, Kana; Tsuchiya, Ayako; Uchida, Takako; Tsuchimoto, Teruhisa; Sodeoka, Mikiko
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 9 p. 2771 - 2782
反应条件
hydrogenchloride; methanol
参考文献
Liwschiz et al.
Zhurnal Obshchei Khimii, 1947 , vol. 17, p. 1671,1675
Chem.Abstr., 1948 , p. 2606
Full Text Show Details
Cohen
Journal of the Chemical Society, 1935 , p. 429,435
反应条件
methanol
Esterification;
参考文献
DeLong, Mitchell A.; Amburgey, Jack; Taylor, Cynthia; Wos, John A.; Soper, David L.; Wang, Yili; Hicks, Renee
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 14 p. 1519 - 1522
反应条件
1: With 4-methyl-morpholine; isopropyloxycarbonylchloride in tetrahydrofuran; toluene
T=0°C; 0.833333 h;
2: With ammonia in tetrahydrofuran; methanol; toluene
T=0 - 20°C; 2 h;
参考文献
Hoffmann-La Roche Inc.; Goodnow, JR., Robert A.; Hamilton, Matthew Michael; Kowalczyk, Agnieszka; Sidduri, Achyutharao
Patent: US2013/197059 A1, 2013 ;
Location in patent: Paragraph 0117; 0118 ;
反应条件
1: 100 percent / thionyl chloride / toluene / 3 h / 55 - 60 °C
2: 1.) aq. sodium azide / 1.) acetone, 0 deg C, 0.5 h, 2.) toluene, 80 deg C, 0.5 h
View Scheme
参考文献
Umezawa; Hoshino; Sawaki; Mori
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 3 p. 1003 - 1005
