3-(3-甲氧基苯基)丙酸合成路线 （共 43 条）
反应条件
1: LiAlH4 / tetrahydrofuran 2: HBr 5: n-Bu4NF / hexamethylphosphoric acid triamide / 2 h / 40 °C 6: 1 M HCl / acetone / 1.5 h / Ambient temperature 7: 30 percent / 0.5 M Na2CO3, 0.5 M K3Fe(CN)6 / 3 h at 0 deg C, then 14 h at 25 deg C 8: diethyl ether View Scheme
参考文献
Leboff, A.; Carbonelle, A.-C.; Alazard, J.-P.; Thal, C.; Kende, A. S.
Tetrahedron Letters, 1987 , vol. 28, # 36 p. 4163 - 4164
反应条件
1: NaI, Me3SiCl / acetonitrile / 4 h / 60 °C 2: H2SO4 / 12 h / 25 °C 3: LiAlH4 / diethyl ether / 6 h / 25 °C View Scheme
参考文献
Allevi, Pietro; Ciuffreda, Pierangela; Longo, Alessandra; Anastasia, Mario
Tetrahedron Asymmetry, 1998 , vol. 9, # 16 p. 2915 - 2924
反应条件
1: polyphosphoric acid 2: LiAlH4 / diethyl ether View Scheme
参考文献
Hofer,O.
Monatshefte fuer Chemie, 1978 , vol. 109, p. 405 - 419
反应条件
chloro-trimethyl-silane; sodium iodide in acetonitrile T=60°C; 4 h;
参考文献
Barlow, James W.; Walsh, John J.
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 1 p. 25 - 37
反应条件
1: 100 percent / thionyl chloride / toluene / 3 h / 55 - 60 °C 2: 1.) aq. sodium azide / 1.) acetone, 0 deg C, 0.5 h, 2.) toluene, 80 deg C, 0.5 h 3: 37 percent / polyphosphoric acid / acetone / 2.5 h / 24 °C View Scheme
参考文献
Umezawa; Hoshino; Sawaki; Mori
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 3 p. 1003 - 1005
反应条件
1: thionyl chloride / benzene 2: 88 percent / triethyl amine / diethyl ether / 1 h / Ambient temperature 3: 59 percent / diethyl ether / 0.5 h / Ambient temperature 4: 24 percent / acetonitrile / Irradiation View Scheme
参考文献
Charlton, James Leslie.; Lai, Hoi Kiong.; Lypka, Gerald Nicholas
Canadian Journal of Chemistry, 1980 , vol. 58, p. 458 - 462
反应条件
1: LiAlH4
2: PCC
3: 75 percent / <OH(CH2)2C3HNC(CH3)Bn>Cl, Et3N / ethanol
View Scheme
参考文献
Hwang, Kwang-Jin; O'Neil, James P.; Katzenellenbogen, John A.
Journal of Organic Chemistry, 1992 , vol. 57, # 4 p. 1262 - 1271
反应条件
1: polyphosphoric acid
2: isoamyl nitrite
View Scheme
参考文献
Mukhopadhyay,D.; Chaudhury,D.N.
Journal of the Indian Chemical Society, 1963 , vol. 40, p. 433 - 436
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
0.666667 h; Heating;
参考文献
F. HOFFMANN-LA ROCHE AG; GILLESPIE, Paul; MICHOUD, Christophe; RUPERT, Kenneth Carey; THAKKAR, Kshitij Chhabilbhai; YI, Lin
Patent: WO2012/123467 A1, 2012 ;
Location in patent: Page/Page column 23 ;
反应条件
1: thionyl chloride / benzene
2: 88 percent / triethyl amine / diethyl ether / 1 h / Ambient temperature
View Scheme
参考文献
Charlton, James Leslie.; Lai, Hoi Kiong.; Lypka, Gerald Nicholas
Canadian Journal of Chemistry, 1980 , vol. 58, p. 458 - 462
