1-(4-甲基苯)哌啶-4-酮合成路线 （共 6 条）
反应条件
in chloroform; water; acetic acid; mineral oil; benzene
参考文献
KING'S COLLEGE LONDON
Patent: EP298982 B1, 1991 ;
反应条件
pyridine; dimethyl sulfoxide; dicyclohexyl-carbodiimide; trifluoroacetic acid in benzene 1) 0 deg C 2) RT, 24 h;
参考文献
Reese, Colin B.; Thompson, Elizabeth A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 2881 - 2886
反应条件
sodium carbonate in methanol 1.2 h; Heating;
参考文献
De Ridder, Dirk J. A.; Goubitz, Kees; Schenk, Henk; Krijnen, Bert; Verhoeven, Jan W.
Helvetica Chimica Acta, 2003 , vol. 86, # 3 p. 799 - 811
反应条件
1: CuCl / acetic acid / Heating 2: 1.) NaH; 2.) conc.HCl / 1.) benzene, reflux; 2.) water, reflux View Scheme
参考文献
Reese, Colin B.; Serafinowska, Halina T.; Zappia, Giovanni
Tetrahedron Letters, 1986 , vol. 27, # 20 p. 2291 - 2294
反应条件
1: 76 percent / NaBH4 / ethanol / 2 h / -5 °C 2: 82 percent / K2CO3, NaI / dimethylformamide / 1.5 h / 100 °C / var.: THF, LDA, -70 deg C 3: 80 percent / DCC, DMSO, pyridine, TFA / benzene / 1) 0 deg C 2) RT, 24 h View Scheme
参考文献
Reese, Colin B.; Thompson, Elizabeth A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 2881 - 2886
反应条件
1: 82 percent / K2CO3, NaI / dimethylformamide / 1.5 h / 100 °C / var.: THF, LDA, -70 deg C 2: 80 percent / DCC, DMSO, pyridine, TFA / benzene / 1) 0 deg C 2) RT, 24 h View Scheme
参考文献
Reese, Colin B.; Thompson, Elizabeth A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 2881 - 2886
