(R)-1-苄基-吡咯烷-2-羰酰氯合成路线 （共 4 条）
反应条件
thionyl chloride 3 h; Ambient temperature;
参考文献
Belokon', Yuri N.; Tararov, Vitali I.; Maleev, Viktor I.; Savel'eva, Tatiana F.; Ryzhov, Michael G.
Tetrahedron Asymmetry, 1998 , vol. 9, # 23 p. 4249 - 4252
反应条件
1: 89 percent / KOH / propan-2-ol / 6 h / 40 °C 2: SOCl2 / CH2Cl2 / -10 °C View Scheme
参考文献
Belokon', Yu. N.; Zel'tzer, I. E.; Bakhmutov, V. I.; Saporovskaya, M. B.; Ryzhov, M. G.; et al.
Journal of the American Chemical Society, 1983 , vol. 105, # 7 p. 2010 - 2017
反应条件
1: 42 percent / 2N NaOH, tetrabutylammonium hydroxide, KI / H2O / 3 h / 65 °C 2: SOCl2 / 3 h / Ambient temperature View Scheme
参考文献
Belokon', Yuri N.; Tararov, Vitali I.; Maleev, Viktor I.; Savel'eva, Tatiana F.; Ryzhov, Michael G.
Tetrahedron Asymmetry, 1998 , vol. 9, # 23 p. 4249 - 4252
反应条件
in dichloromethane
10 h; Ambient temperature; Yield given;
参考文献
SMITHKLINE BEECHAM CORPORATION; ANACOR PHARMACEUTICALS, INC.
Patent: WO2009/46098 A1, 2009 ;
Location in patent: Page/Page column 73-75 ;
