反应条件
1.1: triethylamine / toluene / 3 h / Heating
2.1: n-BuLi; 2,2,6,6-tetramethylpiperidine / hexane; tetrahydrofuran / 0 °C
2.2: hexane; tetrahydrofuran
3.1: n-BuLi; 2,2,6,6-tetramethylpiperidine / hexane; tetrahydrofuran / 0.5 h / 0 °C
3.2: hexane; tetrahydrofuran / 0.5 h / 0 - 20 °C
4.1: 32 percent / LiAlH4 / tetrahydrofuran / 24 h / Heating
5.1: 100 percent / BBr3 / CH2Cl2 / 20 h / 20 °C
View Scheme
参考文献
DeSolms, S. Jane; Ciccarone, Terrence M.; MacTough, Suzanne C.; Shaw, Anthony W.; Buser, Carolyn A.; Ellis-Hutchings, Michelle; Fernandes, Christine; Hamilton, Kelly A.; Huber, Hans E.; Kohl, Nancy E.; Lobell, Robert B.; Robinson, Ronald G.; Tsou, Nancy N.; Walsh, Eileen S.; Graham, Samuel L.; Beese, Lorena S.; Taylor, Jeffrey S.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 14 p. 2973 - 2984
