1,3-丙酮二羧酸二乙酯合成路线 （共 169 条）
反应条件
sulfuric acid T=25°C; 48 h;
参考文献
Brubaker; DeRuiter; Whitmer
Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 1094 - 1099
反应条件
1: benzene; acetic acid; ammonium acetate / 160 °C / Reagens 4: β-Alanin, Reagens 5: Piperidin. Entfernen des gebildeten Wassers. 2: Raney nickel; ethanol; triethylamine / 100 °C / 88260.9 Torr / Hydrogenation View Scheme
参考文献
Takahashi; Kariyone
Yakugaku Zasshi, 1959 , vol. 79, p. 711,716
Chem.Abstr., 1959 , p. 21940
参考文献
Ghosh, Shyamali; Kinney, William A.; Lawson, Edward C.; Luci, Diane K.; Maryanoff, Bruce E.; Sommen, Francois Maria; Pan, Yongchun
Patent: US2008/39454 A1, 2008 ;
Location in patent: Page/Page column 61 ;
US 20080039454 A1
反应条件
1.1: ethylamine / ethanol / 48 h / 20 °C 1.2: 0.17 h / 100 °C 2.1: trichlorophosphate / 24 h / 180 °C 3.1: potassium acetate; hydrogen; palladium on activated charcoal / methanol / 24 h / 20 °C View Scheme
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Jiancun; ZHANG, Yingjun; ZHANG, Weihong; LIU, Bing; ZHANG, Jiquan; LIU, Jinlei; ZHANG, Lu
Patent: WO2013/71697 A1, 2013 ;
反应条件
potassium tert-butylate 1) THF, below 60 deg C; or NaOAc as base; Yield given. Multistep reaction;
参考文献
PFIZER LIMITED
Patent: US2007/197478 A1, 2007 ;
Location in patent: Page/Page column 71-72 ;
反应条件
in water T=15 - 40°C; 1 h;
参考文献
Manoni, Francesco; Connon, Stephen J.
Angewandte Chemie - International Edition, 2014 , vol. 53, # 10 p. 2628 - 2632
Angew. Chem., 2014 , vol. 126, # 10 p. 2666 - 2670,5
反应条件
1: 86 percent / Et3N / ethanol / 168 h / 20 °C 2: 100 percent / CHCl3 / 168 h / 61 °C View Scheme
参考文献
Nishiwaki, Nagatoshi; Nishida, Daisei; Ohnishi, Tetsuya; Hidaka, Fumie; Shimizu, Satoru; Tamura, Mina; Hori, Kazushige; Tohda, Yasuo; Ariga, Masahiro
Journal of Organic Chemistry, 2003 , vol. 68, # 22 p. 8650 - 8656
反应条件
sodium ethanolate Sieden; mehrstuendiges Kochen des Reaktionsprodukts mit HCl (konz.).;
参考文献
English
Journal of the American Chemical Society, 1941 , vol. 63, p. 942
参考文献
Apitzsch; Blezinger
Chemische Berichte, 1908 , vol. 41, p. 4034
反应条件
1: 86 percent / Et3N / ethanol / 168 h / 20 °C 2: 100 percent / CHCl3 / 168 h / 61 °C View Scheme
参考文献
Nishiwaki, Nagatoshi; Nishida, Daisei; Ohnishi, Tetsuya; Hidaka, Fumie; Shimizu, Satoru; Tamura, Mina; Hori, Kazushige; Tohda, Yasuo; Ariga, Masahiro
Journal of Organic Chemistry, 2003 , vol. 68, # 22 p. 8650 - 8656
