1,3-丙酮二羧酸二乙酯合成路线 （共 169 条）
反应条件
1: With acetic anhydride T=120°C; 3 h; 2: With ammonium hydroxide in water Cooling with ice;
参考文献
Montoir, David; Tonnerre, Alain; Duflos, Muriel; Bazin, Marc-Antoine
European Journal of Organic Chemistry, 2014 , vol. 2014, # 7 p. 1487 - 1495
反应条件
ammonia; acetic anhydride in water T=0 - 120°C; 20 h; Inert atmosphere;
参考文献
BIOTA EUROPE LTD; TYNDALL, Edward Malcolm; CZAPLEWSKI, Lloyd George; FISHWICK, Colin William Gordon; YULE, Ian Andrew; MITCHELL, Jeffrey Peter; ANDERSON, Kelly Helen; PITT, Gary Robert William
Patent: WO2013/91011 A1, 2013 ;
Location in patent: Page/Page column 66; 67 ;
反应条件
1: With orthoformic acid triethyl ester T=120°C; 2 h; 2: With ammonia in dichloromethane T=0 - 20°C;
参考文献
Deciphera Pharmaceuticals, LLC; Flynn, Daniel L.; Kaufman, Michael D.; Petillo, Peter A.
Patent: US8461179 B1, 2013 ;
Location in patent: Page/Page column 66 ;
参考文献
FLYNN, Daniel L.; KAUFMAN, Michael D.
Patent: WO2013/184119 A1, 2013 ;
Location in patent: Paragraph 0203 ;
反应条件
morpholine; sulfur in ethanol Gewald reaction; 2 h; Heating;
参考文献
Hongtao, Wei; Jin, Cai; Min, Sun; Min, Ji
Heteroatom Chemistry, 2007 , vol. 18, # 3 p. 236 - 238
反应条件
1: With morpholine in N,N-dimethyl-formamide T=25 - 35°C; 2: With sulfur in N,N-dimethyl-formamide T=25 - 55°C; 3: With water in N,N-dimethyl-formamide T=25 - 55°C;
参考文献
ACTAVIS GROUP PTC EHF; SEBASTIAN, Sonny; PERI, Seetha, Rama, Sarma; JAGADALE, Prashant; PRADHAN, Nitin, Sharadchandra
Patent: WO2011/124992 A1, 2011 ;
Location in patent: Page/Page column 19 ;
反应条件
1: acetic anhydride / 145 °C 2: trichlorophosphate / Reflux 3: lithium hydroxide hydrate / tetrahydrofuran; water / 20 °C View Scheme
参考文献
MANNKIND CORPORATION; TOLERO PHARMACEUTICALS, INC.; ZENG, Qingping; FARIS, Mary; MOLLARD, Alexis; WARNER, Steven L.; FLYNN, Gary A.
Patent: WO2014/52365 A1, 2014 ;
反应条件
1: With sodium ethanolate T=90°C; 2: With hydrogenchloride in water Heating;
参考文献
Bell, Roel P.L.; Verdijk, Dennis; Relou, Mike; Smith, Dennis; Regeling, Henk; Ebbers, Eelco J.; C. Leemhuis, Frank M.; Oniciu, Daniela C.; Cramer, Clay T.; Goetz, Brian; Pape, Michael E.; Krause, Brian R.; Dasseux, Jean-Louis
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 1 p. 223 - 236
反应条件
ammonia Erwaermen des Reaktionsprodukts mit wss. Salzsaeure;
参考文献
Journal of the American Chemical Society, , vol. 79, p. 5439
反应条件
sodium ethanolate Siedend; mehrstuendiges Kochen des entstandenen Tetraaethylesters mit HCl (konz.).;
参考文献
English
Journal of the American Chemical Society, 1941 , vol. 63, p. 942
