1,3-丙酮二羧酸二乙酯合成路线 (共 169 条)
反应条件
ethanol; water
unter Zusatz von wss. Salzsaeure und Erhitzen des Reaktionsprodukts mit geringen Mengen amalgamiertem Zink und wss. Salzsaeure;
参考文献
Anet et al.
Austral. J. scient. Res., 1950 , vol. <A> 3, p. 635,639, 640
反应条件
sulfuric acid
T=25°C; 48 h;
参考文献
Brubaker; DeRuiter; Whitmer
Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 1094 - 1099
反应条件
1.1: triethylamine; 4-Acetylaminobenzenesulfonyl Azide / acetonitrile / 1 h / 0 - 25 °C
2.1: triphenylphosphine / diethyl ether / 20 - 25 °C
2.2: 6 h / 115 °C
View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; MOSLIN, Ryan M.; WEINSTEIN, David S.; WROBLESKI, Stephen T.; TOKARSKI, John S.; KUMAR, Amit
Patent: WO2014/74661 A1, 2014 ;
反应条件
1.1: triethylamine; magnesium chloride / benzene / 1.5 h / |Reflux
2.1: sodium hydride / tetrahydrofuran; paraffin oil / 0.5 h / 20 °C
2.2: 24 h
View Scheme
参考文献
Mbofana, Curren T.; Miller, Scott J.
Journal of the American Chemical Society, 2014 , vol. 136, # 8 p. 3285 - 3292
反应条件
sodium ethanolate in ethanol
T=0 - 5°C;
参考文献
Bertelli, Lucia; Biagi, Giuliana; Giorgi, Irene; Livi, Oreste; Manera, Clementina; Scartoni, Valerio; Martini, Claudia; Giannaccini, Gino; Trincavelli, Letizia; Barili, Pier Luigi
Farmaco, 1998 , vol. 53, # 4 p. 305 - 311
反应条件
magnesium diethoxide in ethanol
10 h; Heating;
参考文献
Kitahara, Takeshi; Mori, Kenji; Matsui, Masanao; Iwamoto, Minoru; Takagi, Yoshikazu; Warita, Yasuhiro
Agricultural and Biological Chemistry, 1982 , vol. 46, # 5 p. 1369 - 1376
反应条件
toluene-4-sulfonic acid
5 h; RefluxDean-Stark;
参考文献
Yang, Donglai; Arifhodzic, Lejla; Ganellin, C. Robin; Jenkinson, Donald H.
European Journal of Medicinal Chemistry, 2013 , vol. 63, p. 907 - 923
反应条件
1: 86 percent / Et3N / ethanol / 168 h / 20 °C
2: 100 percent / CHCl3 / 24 h / 20 °C
View Scheme
参考文献
Nishiwaki, Nagatoshi; Nishida, Daisei; Ohnishi, Tetsuya; Hidaka, Fumie; Shimizu, Satoru; Tamura, Mina; Hori, Kazushige; Tohda, Yasuo; Ariga, Masahiro
Journal of Organic Chemistry, 2003 , vol. 68, # 22 p. 8650 - 8656
反应条件
in pyridine
4 h; Heating;
参考文献
Zayed, M. A.; Abou-Taleb, Salah A.; El-Morsy, M. M. S.
Journal of the Indian Chemical Society, 1982 , vol. 59, # 8 p. 1013 - 1015
反应条件
in pyridine
4 h; Heating;
参考文献
Zayed, M. A.; Abou-Taleb, Salah A.; El-Morsy, M. M. S.
Journal of the Indian Chemical Society, 1982 , vol. 59, # 8 p. 1013 - 1015