3,5-二甲基-4-甲氧基吡啶-2-甲腈合成路线 （共 6 条）
反应条件
pyridine; trifluoroacetic anhydride in dichloromethane Ambient temperature;
参考文献
Development Center for Biotechnology
Patent: US5625069 A1, 1997 ;
反应条件
1: 84 percent / anh. potassium carbonate / acetone / 34 h / Heating 2: 20 percent / sodium ethoxide / ethanol / 0.5 h / Heating 3: 92 percent / sulfuric acid / 4 h / Heating 4: 91 percent / ammonia / ethanol / 48 h / 120 °C 5: 90 percent / anh. potassium carbonate / acetone / 15 h / Heating 6: 91 percent / pyridine, trifluoroacetic anhydride / CH2Cl2 / Ambient temperature View Scheme
参考文献
Chou, Shan-Yen; Chen, Shyh-Fong
Heterocycles, 1997 , vol. 45, # 1 p. 77 - 85
反应条件
1: 92 percent / sulfuric acid / 4 h / Heating 2: 91 percent / ammonia / ethanol / 48 h / 120 °C 3: 90 percent / anh. potassium carbonate / acetone / 15 h / Heating 4: 91 percent / pyridine, trifluoroacetic anhydride / CH2Cl2 / Ambient temperature View Scheme
参考文献
Chou, Shan-Yen; Chen, Shyh-Fong
Heterocycles, 1997 , vol. 45, # 1 p. 77 - 85
反应条件
1: 91 percent / ammonia / ethanol / 48 h / 120 °C 2: 90 percent / anh. potassium carbonate / acetone / 15 h / Heating 3: 91 percent / pyridine, trifluoroacetic anhydride / CH2Cl2 / Ambient temperature View Scheme
参考文献
Chou, Shan-Yen; Chen, Shyh-Fong
Heterocycles, 1997 , vol. 45, # 1 p. 77 - 85
反应条件
sodium hydroxide; thionyl chloride; sodium nitrite; nickel monoaluminide in NH3 -saturated methanol; water; acetic acid
参考文献
CL Pharma Aktiengesellschaft
Patent: US5066810 A1, 1991 ;
反应条件
ammonia; nickel monoaluminide in NH3 -saturated methanol
