2-甲基-3-氧代-3-苯基丙酸乙酯合成路线 （共 76 条）
反应条件
1: ethyl 3-oxo-3-phenylpropionate With sodium hydride in tetrahydrofuran; mineral oil T=20°C; Inert atmosphere; 2: methyl iodide in tetrahydrofuran; mineral oil T=20°C; 20 h; Inert atmosphere;
参考文献
Gonzalez, Davinia Fernandez; Brand, Jonathan P.; Waser, Jerome
Chemistry - A European Journal, 2010 , vol. 16, # 31 p. 9457 - 9461
反应条件
sodium hydride in tert-butyl methyl ether Claisen condensation; Inert atmosphereReflux;
参考文献
Bertogg, Andreas; Hintermann, Lukas; Huber, Dominique P.; Perseghini, Mauro; Sanna, Maria; Togni, Antonio
Helvetica Chimica Acta, 2012 , vol. 95, # 3 p. 353 - 403
反应条件
oxalyl dichloride; dimethyl sulfoxide; triethylamine in dichloromethane T=-60°C; 0.333333 h;
参考文献
Smith, Amos B.; Levenberg, Patricia A.
Synthesis, 1981 , # 7 p. 567 - 570
反应条件
1: diazoacetic acid ethyl ester; PhC(O)TMS With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 0.5 h; 2: methyl iodide in tetrahydrofuran T=-78 - 0°C; Further stages.;
参考文献
Galliford, Chris V.; Scheidt, Karl A.
Chemical Communications, 2008 , # 16 p. 1926 - 1928
反应条件
1: ethyl 2-trimethylsilyloxycinnamate With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 1 h; 2: methyl iodide in tetrahydrofuran T=23°C; 16 h; Further stages.;
参考文献
Galliford, Chris V.; Scheidt, Karl A.
Chemical Communications, 2008 , # 16 p. 1926 - 1928
反应条件
Bis(3-morpholinylpropyl)phenylphosphine in dichloromethane
参考文献
Shiosaki, Kazumi; Fels, Gregor; Rapoport, Henry
Journal of Organic Chemistry, 1981 , vol. 46, # 16 p. 3230 - 3234
反应条件
1: 2-methyl-3-oxobutanoic acid ethyl ester With sodium hydride in tetrahydrofuran T=20°C; 0.666667 h; 2: PhCOBt in tetrahydrofuran T=20°C;
参考文献
Journal of Organic Chemistry, , vol. 69, # 20 p. 6617 - 6622
反应条件
2,2'-azo-bisisobutyronitrile; tri-n-butyl-tin hydride in benzene insertion; Heating;
参考文献
Journal of Organic Chemistry, , vol. 64, # 21 p. 7836 - 7841
反应条件
1: T=80°C; Eschenmoser coupling; 2: With triethylamine; tris-(dimethylamino)-phosphine in acetonitrile Heating;
参考文献
Bellec, Christian; Gaurat, Olivier
Canadian Journal of Chemistry, 2004 , vol. 82, # 8 p. 1289 - 1293
反应条件
zinc in tetrahydrofuran 1 h; Heating;
参考文献
Kashima, Choji; Kita, Isanobu; Takahashi, Katsumi; Hosomi, Akira
Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 3 p. 723 - 726
