(3-氟-4,5-二羟基苯基)乙腈合成路线 （共 3 条）
反应条件
boron tribromide in dichloromethane T=25°C; 18 h;
参考文献
Clark, Michael T.; Adejare, Adeboye; Shams, Gamal; Feller, Dennis R.; Miller, Duane D.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 86 - 90
反应条件
1: 95 percent / ethanol; H2O / 2 h / Heating 2: 1.) MeI / 1.) CHCl3, 25 deg C, 18 h, 2.) DMSO, 25 deg C, 7 h 3: 90.1 percent / BBr3 / CH2Cl2 / 18 h / 25 °C View Scheme
参考文献
Clark, Michael T.; Adejare, Adeboye; Shams, Gamal; Feller, Dennis R.; Miller, Duane D.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 86 - 90
反应条件
1: 1.) MeI / 1.) CHCl3, 25 deg C, 18 h, 2.) DMSO, 25 deg C, 7 h 2: 90.1 percent / BBr3 / CH2Cl2 / 18 h / 25 °C View Scheme
参考文献
Clark, Michael T.; Adejare, Adeboye; Shams, Gamal; Feller, Dennis R.; Miller, Duane D.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 86 - 90
