1,1'-联(环己烷)-1'-烯-2-胺合成路线 （共 35 条）
反应条件
(i) LDA, (ii) aq. AcOH; Multistep reaction;
参考文献
Jacobson,R.M. et al.
Journal of Organic Chemistry, 1978 , vol. 43, # 24 p. 4650 - 4652
反应条件
(i) EtMgBr, THF, (ii) /BRN= 1697479/; Multistep reaction;
参考文献
Eadon,G.; Djerassi,C.
Journal of the American Chemical Society, 1969 , vol. 91, # 10 p. 2724 - 2727
反应条件
1.1: lithium diisopropylamide / tetrahydrofuran / 0.5 h / 0 °C
1.2: tetrahydrofuran / 0.67 h / -18 °C
2.1: 485 mg / oxalic acid / tetrahydrofuran; H2O / 6 h / 27 °C
3.1: 81 percent / sulfuryl chloride / CCl4 / 0 - 22 °C
View Scheme
参考文献
Muratake, Hideaki; Natsume, Mitsutaka; Nakai, Hiroshi
Tetrahedron, 2004 , vol. 60, # 51 p. 11783 - 11803
反应条件
1.1: lithium diisopropylamide / tetrahydrofuran / 0.5 h / 0 °C
1.2: tetrahydrofuran / 0.67 h / -18 °C
2.1: 485 mg / oxalic acid / tetrahydrofuran; H2O / 6 h / 27 °C
3.1: 81 percent / sulfuryl chloride / CCl4 / 0 - 22 °C
4.1: 74 percent / LiBr; Li2CO3 / dimethylformamide / 1 h / 120 °C
View Scheme
参考文献
Muratake, Hideaki; Natsume, Mitsutaka; Nakai, Hiroshi
Tetrahedron, 2004 , vol. 60, # 51 p. 11783 - 11803
反应条件
1.1: lithium diisopropylamide / tetrahydrofuran / 1 h / -18 °C
1.2: 95 percent / oxalic acid / tetrahydrofuran; H2O / 0 - 27 °C
2.1: NaI; TMSCl; (TMS)2NH / acetonitrile / 4 h / 0 °C
2.2: 80 percent / N-bromosuccinimide / tetrahydrofuran / 14 h / -18 - 23 °C
View Scheme
参考文献
Muratake, Hideaki; Natsume, Mitsutaka; Nakai, Hiroshi
Tetrahedron, 2004 , vol. 60, # 51 p. 11783 - 11803
反应条件
Yield given. Multistep reaction;
参考文献
Clive, Derrick L. J.; Beaulieu, Pierre L.; Set, Lu
Journal of Organic Chemistry, 1984 , vol. 49, p. 1313 - 1314
反应条件
Yield given. Multistep reaction;
参考文献
Clive, Derrick L. J.; Beaulieu, Pierre L.; Set, Lu
Journal of Organic Chemistry, 1984 , vol. 49, p. 1313 - 1314
反应条件
1.1: lithium diisopropylamide / tetrahydrofuran / 0.5 h / 0 °C
1.2: tetrahydrofuran / 0.67 h / -18 °C
2.1: 485 mg / oxalic acid / tetrahydrofuran; H2O / 6 h / 27 °C
View Scheme
参考文献
Muratake, Hideaki; Natsume, Mitsutaka; Nakai, Hiroshi
Tetrahedron, 2004 , vol. 60, # 51 p. 11783 - 11803
反应条件
2: acetonitrile / 15 h / Heating
View Scheme
参考文献
Ahlbrecht, Hubertus; Daacke, Axel von
Synthesis, 1984 , # 7 p. 610 - 614
参考文献
Ibragimov, A. G.; Minsker, D. L.; Morozov, A. B.; Galkin, E. M.; Dzhemilev, U. M.; Tolstikov, G. A.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1990 , vol. 39, # 1.2 p. 140 - 144
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1990 , # 1 p. 155 - 160
