4,5-二溴-3-硝基-1H-吡唑合成路线 （共 4 条）
反应条件
1: 3,4,5-tribromo-1H-pyrazole With nitric acid; acetic anhydride; acetic acid T=10 - 20°C; 3.33333 h; 2: 3,5-dimethyl-1H-pyrazole in toluene 0.333333 h; Reflux;
参考文献
Boivin, Roch; Carlson, Eric; Endo, Atsushi; Hansen, Hans; Hawkins, Lynn D.; Ishizaka, Sally; Mackey, Matthew; Narayan, Sridhar; Satoh, Takashi; Schiller, Shawn
Patent: US2013/324547 A1, 2013 ;
Location in patent: Paragraph 0520 ;
反应条件
sodium hydroxide; bromine in water 3 h;
参考文献
Juffermans, J. P. H.; Habraken, Clarisse L.
Journal of Organic Chemistry, 1986 , vol. 51, # 24 p. 4656 - 4660
反应条件
3,5-dimethyl-1H-pyrazole in toluene 0.333333 h; Inert atmosphereReflux;
参考文献
Moy, Franklin J.; Lee, Arthur; Gavrin, Lori Krim; Xu, Zhang Bao; Sievers, Annette; Kieras, Elizabeth; Stochaj, Wayne; Mosyak, Lidia; McKew, John; Tsao, Desiree H. H.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 3 p. 1238 - 1249
反应条件
SnCl2·2H2O in ethanol; ethyl acetate T=110°C; 0.75 h;
参考文献
Boivin, Roch; Carlson, Eric; Endo, Atsushi; Hansen, Hans; Hawkins, Lynn D.; Ishizaka, Sally; Mackey, Matthew; Narayan, Sridhar; Satoh, Takashi; Schiller, Shawn
Patent: US2013/324547 A1, 2013 ;
Location in patent: Paragraph 0521 ;
