hydrogenchloride in ethyl acetate T=0 - 20°C;

hydrogenchloride in ethanol Product distribution / selectivity;

sodium hydroxide in ethanol T=20°C; 0.5 h; Product distribution / selectivity;

1: 2-(methanesulphonyl)ethylamine hydrochloride; 5-(4-[3-chloro-4-(3-fluorobenzyloxy)-anilino]-6-quinazolinyl)-furan-2-carbaldehyde With acetic acid; N-ethyl-N,N-diisopropylamine in tetrahydrofuran; N,N-dimethyl-formamide T=35°C; 1 h; 2: With sodium tris(acetoxy)borohydride in tetrahydrofuran; N,N-dimethyl-formamide T=20 - 25°C; 2 h; 3: toluene-4-sulfonic acid

1: 5-(4-[3-chloro-4-(3-fluorobenzyloxy)-anilino]-6-quinazolinyl)-furan-2-carbaldehyde 4-methylbenzenesulfonate; 2-(methanesulphonyl)ethylamine hydrochloride With acetic acid; N-ethyl-N,N-diisopropylamine in methanol T=5 - 10°C; 1 h; 2: With sodium cyanoborohydride in methanol T=5 - 10°C; 19 h; 3: toluene-4-sulfonic acid Product distribution / selectivity;

1: With acetic acid; N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=40°C; 1 h; 2: With sodium tris(acetoxy)borohydride in tetrahydrofuran T=20°C; 3 h;

1: 2-(methanesulphonyl)ethylamine hydrochloride With acetic acid; N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=20°C; 0.5 h; 2: 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde hydrochloride With water in tetrahydrofuran T=20°C; 4 h; 3: With sodium tris(acetoxy)borohydride in tetrahydrofuran

1: With acetic acid; N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=30 - 35°C; 1 h; 2: With sodium tris(acetoxy)borohydride in tetrahydrofuran T=22°C; 2.25 h;