2-乙酰基-4-氰基丁酸乙酯合成路线 （共 19 条）
反应条件
sodium methylate T=40 - 45°C; 4 h;
参考文献
Ozaki; Watanabe; Nagase; et al.
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 2 p. 893 - 896
反应条件
4-(N,N-dimethlyamino)pyridine in water T=20°C; Michael addition reaction; 43 h;
参考文献
Ko, Kyungmin; Nakano, Keiji; Watanabe, Shigeru; Ichikawa, Yoshiyasu; Kotsuki, Hiyoshizo
Tetrahedron Letters, 2009 , vol. 50, # 28 p. 4025 - 4029
反应条件
pentacarbonyliron(0); bromine T=120 - 130°C;
参考文献
Amriev, R.A.; Velichko, F.K.; Abdulkina, Z.A.; Freidlina, R.Kh.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1984 , vol. 33, # 11 p. 2335 - 2339
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1984 , # 11 p. 2550 - 2555
参考文献
Keimatsu; Sugasawa
Yakugaku Zasshi, 1928 , vol. 48, p. 105
Chem. Zentralbl., 1928 , vol. 99, # II p. 1882
反应条件
1: Raney nickel; H2 / tetrahydrofuran / 15 h / 80 °C / 34200 Torr 2: 115 mg / H2O / 5 h / 100 °C View Scheme
参考文献
Tetrahedron, , vol. 61, # 1 p. 115 - 122
反应条件
1: HCl / CHCl3 2: 30 percent Pd/C View Scheme
参考文献
Ruyun, Ji
Medicinal Chemistry Research, 1995 , vol. 5, # 8 p. 587 - 594
反应条件
1: sulfuric acid 2: sodium View Scheme
参考文献
Nakazawa; Matsuura
Yakugaku Zasshi, 1951 , vol. 71, p. 802
Chem.Abstr., 1952 , p. 8025
反应条件
1: aq. Na2CO3 2: KBH4 3: HCl / diethyl ether / -10 °C View Scheme
参考文献
Bulletin de la Societe Chimique de France, , p. 3881 - 3888
反应条件
sodium carbonate in water 4 h; Heating;
参考文献
Ozaki; Watanabe; Nagase; et al.
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 2 p. 893 - 896
反应条件
1: aqueous sodium carbonate-solution 2: Raney nickel; ethanol / Hydrogenation View Scheme
参考文献
Albertson
Journal of the American Chemical Society, 1950 , vol. 72, p. 2594,2597
Journal of the American Chemical Society, 1952 , vol. 74, p. 249,250
