1α,25-二羟基-2β-(3-羟基丙氧基)维生素D3合成路线 （共 32 条）
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / -78 °C 1.2: BF3*OEt2 / tetrahydrofuran; hexane / -78 - 20 °C 1.3: 90 percent / K2CO3 / methanol / 20 °C 2.1: 100 percent / 2,6-lutidine / CH2Cl2 / 0 °C 3.1: 52 percent / Et3N; Pd(PPh3)4 / toluene / Heating 4.1: 61 percent / TBAF / tetrahydrofuran / 96 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 22 p. 7463 - 7471
反应条件
1.1: pyridine / 20 °C 2.1: 1.4 g / LiHMDS / tetrahydrofuran / 1 h / -78 - 0 °C 3.1: n-BuLi / tetrahydrofuran; hexane / -78 °C 3.2: BF3*OEt2 / tetrahydrofuran; hexane / -78 - 20 °C 3.3: 90 percent / K2CO3 / methanol / 20 °C 4.1: 100 percent / 2,6-lutidine / CH2Cl2 / 0 °C 5.1: 52 percent / Et3N; Pd(PPh3)4 / toluene / Heating 6.1: 61 percent / TBAF / tetrahydrofuran / 96 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 22 p. 7463 - 7471
反应条件
1: PPh3, DEAd 2: 65 percent 3: NaOH / H2O 5: DDQ 6: 1.) Red-Al, 2.) I2 7: Pd(PPh3)4, Et3N 8: NCS, Me2SO / CH2Cl2 10: H2O2 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 22 p. 2871 - 2874
反应条件
2: DDQ 3: 1.) Red-Al, 2.) I2 4: Pd(PPh3)4, Et3N 5: NCS, Me2SO / CH2Cl2 7: H2O2 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 22 p. 2871 - 2874
反应条件
1: 65 percent 2: NaOH / H2O 4: DDQ 5: 1.) Red-Al, 2.) I2 6: Pd(PPh3)4, Et3N 7: NCS, Me2SO / CH2Cl2 9: H2O2 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 22 p. 2871 - 2874
反应条件
1: aq. HCl 2: PPh3, DEAd 3: 65 percent 4: NaOH / H2O 6: DDQ 7: 1.) Red-Al, 2.) I2 8: Pd(PPh3)4, Et3N 9: NCS, Me2SO / CH2Cl2 11: H2O2 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 22 p. 2871 - 2874
反应条件
1: 1.) Red-Al, 2.) I2 2: Pd(PPh3)4, Et3N 3: NCS, Me2SO / CH2Cl2 5: H2O2 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 22 p. 2871 - 2874
反应条件
1: Pd(PPh3)4, Et3N 2: NCS, Me2SO / CH2Cl2 4: H2O2 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 22 p. 2871 - 2874
反应条件
1: NaOH / H2O 3: DDQ 4: 1.) Red-Al, 2.) I2 5: Pd(PPh3)4, Et3N 6: NCS, Me2SO / CH2Cl2 8: H2O2 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 22 p. 2871 - 2874
反应条件
1: Et3N 2: aq. HCl 3: PPh3, DEAd 4: 65 percent 5: NaOH / H2O 7: DDQ 8: 1.) Red-Al, 2.) I2 9: Pd(PPh3)4, Et3N 10: NCS, Me2SO / CH2Cl2 12: H2O2 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 22 p. 2871 - 2874
