反应条件
1: 30 percent / phosphoryl chloride / 12 h
2: 81.5 percent / piperidine, glacial acetic acid / benzene / Heating
3: 2.) NaOH / 1.) water, ethanol, heating, 2 h, 2.) ethylene glycol, heating, 40 h
4: 1.) acetic anhydride, 2.) ammonia / 1.) heating, 6 h, 2.) ethyl acetate, 2 h
5: 1 h / 200 - 220 °C
View Scheme
参考文献
Nesunts, N. S.; Avetisyan, S. A.; Dzhagatspanyan, I. A.; Akopyan, N. E.; Mndzhoyan, O. L.
Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 7 p. 480 - 484
Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 7 p. 801 - 806
