4-碘-[2-(1-哌啶基)乙氧基l]苯合成路线 （共 3 条）
反应条件
potassium carbonate in acetone T=56°C; 3 h;
参考文献
Li, Xun; Reuman, Michael; Russell, Ronald K.; Adams, Richard; Ma, Robert; Beish, Sandra; Branum, Shawn; Youells, Scott; Roberts, Jerry; Jain, Nareshkumar; Kanojia, Ramesh; Sui, Zhihua
Organic Process Research and Development, 2007 , vol. 11, # 3 p. 414 - 421
反应条件
1: 4-[2-(piperidin-1-yl)-ethoxy]-iodobenzene With n-butyllithium in tetrahydrofuran; pentane
T=-78°C; 1.08333 h;
2: 2,8-bis(tert-butyl-dimethyl-silyloxy)-5,11-dihydro-chromeno[4,3-c]chromen-5-ol in tetrahydrofuran; pentane
1.16667 h;
3: With hydrogenchloride in water; toluene
T=20°C; 0.5 h; Product distribution / selectivity;
参考文献
Kanojia, Ramesh M.; Jain, Nareshkumar F.; Ng, Raymond; Sui, Zhihua; Xu, Jiayi
Patent: US2003/216463 A1, 2003 ;
Location in patent: Page/Page column 58 ;
US 20030216463 A1
反应条件
n-butyllithium; ammonium chloride; sodium hydrogencarbonate in tetrahydrofuran; pentane
参考文献
Kanojia, Ramesh M.; Jain, Nareshkumar F.; Ng, Raymond; Sui, Zhihua; Xu, Jiayi
Patent: US2003/216463 A1, 2003 ;
Location in patent: Page/Page column 61 ;
US 20030216463 A1
