2-(5-甲基-2-苯基-1,3-噁唑-4-基)乙酸甲酯合成路线 （共 15 条）
反应条件
trichlorophosphate in toluene T=140°C; 4 h;
参考文献
LG Life Sciences Ltd.
Patent: WO2005/40127 A1, 2005 ;
Location in patent: Page/Page column 97 ;
WO 2005/040127 A1
反应条件
1: With sulfuric acid; water T=40°C; 6.75 h; Heating / reflux; 2: With water; sodium hydrogencarbonate T=25°C; pH=9 - 10;
参考文献
DSM FINE CHEMICALS AUSTRIA NFG GMBH and CO KG
Patent: WO2006/108493 A1, 2006 ;
Location in patent: Page/Page column 6 ;
参考文献
Liu, Jingbao; Jiang, Faqin; Jiang, Xizhen; Zhang, Wei; Liu, Jingjing; Liu, Wenlu; Fu, Lei
European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 879 - 886
反应条件
trichlorophosphate in toluene 2 h; Heating;
参考文献
Sohda; Mizuno; Momose; Ikeda; Fujita; Meguro
Journal of Medicinal Chemistry, 1992 , vol. 35, # 14 p. 2617 - 2626
反应条件
in ethanol; ethyl acetate; toluene
参考文献
SmithKline Beecham Corporation
Patent: US6498174 B1, 2002 ;
反应条件
1: pyridine, 4-dimethylaminopyridine (DMAP) / 2 h / bath 90 deg C 2: POCl3 / toluene / 5 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 34, # 7 p. 2840 - 2851
反应条件
1: triethylamine / CH2Cl2 / 1 h / ice cooling 2: pyridine, 4-dimethylaminopyridine (DMAP) / 2 h / bath 90 deg C 3: POCl3 / toluene / 5 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 34, # 7 p. 2840 - 2851
反应条件
1: bromine / chloroform / 0 - 20 °C 2: toluene / Reflux View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 46, # 9 p. 3639 - 3650
反应条件
in diethyl ether; water; ethyl acetate
参考文献
Takeda Chemical Industries, Ltd.
Patent: US4725610 A1, 1988 ;
反应条件
sodium borohydride in tetrahydrofuran; hexane; water; ethyl acetate
参考文献
Japan Tobacco Inc.
Patent: US6248897 B1, 2001 ;
