1-[2-(苯氧基)乙基]-4-苯基哌嗪合成路线 （共 5 条）
反应条件
lithium carbonate in acetonitrile 24 h; RefluxInert atmosphere;
参考文献
Romeiro, Luiz A.S.; Da Silva Ferreira, Marcos; Da Silva, Leandro L.; Castro, Helena C.; Miranda, Ana L.P.; Silva, Claudia L.M.; Noel, Franois; Nascimento, Jessica B.; Araujo, Claudia V.; Tibirica, Eduardo; Barreiro, Eliezer J.; Fraga, Carlos A.M.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 3000 - 3012
参考文献
Swain; Naegele
Journal of the American Chemical Society, 1954 , vol. 76, p. 5091
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McNeil Labor. Inc.
Patent: US2695295 , 1952 ;
反应条件
1: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere 2: lithium carbonate / acetonitrile / 24 h / Reflux; Inert atmosphere View Scheme
参考文献
Romeiro, Luiz A.S.; Da Silva Ferreira, Marcos; Da Silva, Leandro L.; Castro, Helena C.; Miranda, Ana L.P.; Silva, Claudia L.M.; Noel, Franois; Nascimento, Jessica B.; Araujo, Claudia V.; Tibirica, Eduardo; Barreiro, Eliezer J.; Fraga, Carlos A.M.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 3000 - 3012
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 20 °C 2: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere 3: lithium carbonate / acetonitrile / 24 h / Reflux; Inert atmosphere View Scheme
参考文献
Romeiro, Luiz A.S.; Da Silva Ferreira, Marcos; Da Silva, Leandro L.; Castro, Helena C.; Miranda, Ana L.P.; Silva, Claudia L.M.; Noel, Franois; Nascimento, Jessica B.; Araujo, Claudia V.; Tibirica, Eduardo; Barreiro, Eliezer J.; Fraga, Carlos A.M.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 3000 - 3012
反应条件
1: potassium carbonate / acetone / 3 h / 20 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 20 °C 3: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere 4: lithium carbonate / acetonitrile / 24 h / Reflux; Inert atmosphere View Scheme
参考文献
Romeiro, Luiz A.S.; Da Silva Ferreira, Marcos; Da Silva, Leandro L.; Castro, Helena C.; Miranda, Ana L.P.; Silva, Claudia L.M.; Noel, Franois; Nascimento, Jessica B.; Araujo, Claudia V.; Tibirica, Eduardo; Barreiro, Eliezer J.; Fraga, Carlos A.M.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 3000 - 3012
