1-((2R,3r,4r,5r)-5-((双(4-甲氧基苯基)(苯基)甲氧基)甲基)-4-羟基-3-甲氧基四氢呋喃-2-基)嘧啶-2,4(1h,3h)-二酮合成路线 (共 7 条)
反应条件
in N,N-dimethyl-formamide T=100°C;
参考文献
Buettner, Lea; Seikowski, Jan; Wawrzyniak, Katarzyna; Ochmann, Anne; Hoebartner, Claudia
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 20 p. 6171 - 6180
反应条件
pyridine in methanol
参考文献
ISIS Pharmaceuticals, Inc.
Patent: US5914396 A1, 1999 ;
反应条件
tin(ll) chloride in 1,4-dioxane; ethylene glycol dimethyl ether 0.333333 h; Ambient temperature;
参考文献
Helvetica Chimica Acta, , vol. 79, # 8 p. 2114 - 2136
反应条件
pyridine 0.75 h; Inert atmosphere;
参考文献
Barbeyron, Renaud; Wengel, Jesper; Vasseur, Jean-Jacques; Smietana, Michael
Monatshefte fur Chemie, 2013 , vol. 144, # 4 p. 495 - 500
反应条件
1: pyridine / 6 h / 20 °C 2: N,N-dimethyl-formamide / 100 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 21, # 20 p. 6171 - 6180
反应条件
1: carbonic acid diphenyl ester; sodium hydrogencarbonate / N,N-dimethyl-formamide / 4 h / 120 °C 2: pyridine / 6 h / 20 °C 3: N,N-dimethyl-formamide / 100 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 21, # 20 p. 6171 - 6180
反应条件
pyridinium trifluoroacetate in dichloromethane T=20°C; 2 h; Inert atmosphere;
参考文献
Organic Process Research and Development, , vol. 4, # 3 p. 175 - 181