2-(6-三氟甲基吡啶-3-基)丙-2-醇合成路线 （共 5 条）
反应条件
1: in tetrahydrofuran; tert-butyl methyl ether T=5 - 25°C; 2: With hydrogenchloride; water in tetrahydrofuran; tert-butyl methyl ether T=0 - 5°C;
参考文献
ELI LILLY AND COMPANY
Patent: WO2008/70305 A2, 2008 ;
Location in patent: Page/Page column 12-13 ;
WO 2008/070305 A2
反应条件
1: 5-bromo-2-(trifluoromethyl)pyridine With n-butyllithium in hexane; toluene T=-75 - -60°C; 0.833333 h; 2: acetone in tetrahydrofuran; hexane T=-60 - -25°C; 1.25 h;
参考文献
Butcher, Kenneth J.; Denton, Steven M.; Field, Stuart E.; Gillmore, Adam T.; Harbottle, Gareth W.; Howard, Roger M.; Laity, Daniel A.; Ngono, Christian J.; Pibworth, Benjamin A.
Organic Process Research and Development, 2011 , vol. 15, # 5 p. 1192 - 1200
反应条件
in tetrahydrofuran T=-10°C; 2 h;
参考文献
Butcher, Kenneth J.; Denton, Steven M.; Field, Stuart E.; Gillmore, Adam T.; Harbottle, Gareth W.; Howard, Roger M.; Laity, Daniel A.; Ngono, Christian J.; Pibworth, Benjamin A.
Organic Process Research and Development, 2011 , vol. 15, # 5 p. 1192 - 1200
反应条件
1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-ethyl-N,N-diisopropylamine / 12 h / 100 °C / 2585.81 Torr 2: tetrahydrofuran / 2 h / -10 °C View Scheme
参考文献
Butcher, Kenneth J.; Denton, Steven M.; Field, Stuart E.; Gillmore, Adam T.; Harbottle, Gareth W.; Howard, Roger M.; Laity, Daniel A.; Ngono, Christian J.; Pibworth, Benjamin A.
Organic Process Research and Development, 2011 , vol. 15, # 5 p. 1192 - 1200
反应条件
toluene-4-sulfonic acid in toluene
6 h; Reflux;
参考文献
Butcher, Kenneth J.; Denton, Steven M.; Field, Stuart E.; Gillmore, Adam T.; Harbottle, Gareth W.; Howard, Roger M.; Laity, Daniel A.; Ngono, Christian J.; Pibworth, Benjamin A.
Organic Process Research and Development, 2011 , vol. 15, # 5 p. 1192 - 1200
