1: 3,4,5-trimethoxyphenylboronic acid With NiI2; trans-2-aminocyclohexanol hydrochloride; sodium hexamethyldisilazane in isopropyl alcohol Inert atmosphere; 2: 3-iodo-oxetane in isopropyl alcohol T=80°C; Suzuki coupling; 0.333333 h; Microwave irradiation;

Yield given. Multistep reaction;

dinitrogen pentaoxide in dichloromethane T=0°C; 0.0833333 h;

nitric acid in dichloromethane Ambient temperature; Rate constantKineticsMechanism;