1-苄基-4-哌啶甲酸甲酯合成路线 （共 9 条）
反应条件
triethylamine in tetrahydrofuran T=0 - 20°C; Inert atmosphere;
参考文献
Moosa, Basem A.; Ali, Shaikh A.
Arkivoc, 2010 , vol. 2010, # 10 p. 132 - 148
反应条件
triethylamine in dichloromethane T=20°C; Alkylation;
参考文献
Alfaro-Lopez, Josue; Okayama, Toru; Hosohata, Keiko; Davis, Peg; Porreca, Frank; Yamamura, Henry I.; Hruby, Victor J.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 26 p. 5359 - 5368
反应条件
potassium carbonate in acetonitrile 3 h; Heating / reflux;
参考文献
WO2008/31227 A1, ;
Page/Page column 37 ;
反应条件
1: 84 percent / SOCl2 / 20 h / 20 °C 2: 79.7 percent / Et3N / CH2Cl2 / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 42, # 26 p. 5359 - 5368
反应条件
Hydrieren des Reaktionsprodukts an Platin in Aether;
参考文献
Journal of the American Chemical Society, , vol. 81, p. 704,707
反应条件
in tetrahydrofuran T=0 - 20°C; Inert atmosphere;
参考文献
Moosa, Basem A.; Ali, Shaikh A.
Arkivoc, 2010 , vol. 2010, # 10 p. 132 - 148
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 5 h; Heating;
参考文献
Rodriguez-Franco, Maria Isabel; Fernandez-Bachiller, Maria Isabel
Synthesis, 2002 , # 7 p. 911 - 915
反应条件
1: 69.5 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 50 °C 2: 94.3 percent / oxalyl chloride; dimethyl sulfoxide; Et3N / CH2Cl2 / 0.25 h / -55 °C View Scheme
参考文献
Alfaro-Lopez, Josue; Okayama, Toru; Hosohata, Keiko; Davis, Peg; Porreca, Frank; Yamamura, Henry I.; Hruby, Victor J.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 26 p. 5359 - 5368
反应条件
hydrogenchloride; water
Heating / reflux;
参考文献
NEUROMED PHARMACEUTICALS LTD.
Patent: WO2008/31227 A1, 2008 ;
Location in patent: Page/Page column 37 ;
