4-(1,3-二氧代异吲哚啉-2-基)丁酰氯合成路线 （共 16 条）
反应条件
oxalyl dichloride in dichloromethane 6 h; Heating;
参考文献
Guenin, Erwann; Monteil, Maelle; Bouchemal, Nadia; Prange, Thierry; Lecouvey, Marc
European Journal of Organic Chemistry, 2007 , # 20 p. 3380 - 3391
反应条件
1: 100 percent / 6 h / 170 °C 2: 100 percent / oxalyl chloride / CH2Cl2 / 6 h / Heating View Scheme
参考文献
Elz, Sigurd; Schunack, Walter
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1987 , vol. 42, # 2 p. 238 - 242
反应条件
1: 96 percent / 0.5 h / 180 °C 2: SOCl2 / tetrahydrofuran / 2 h / 50 °C View Scheme
参考文献
Apelt; Grassmann; Ligneau; Pertz; Ganellin; Arrang; Schwartz; Schunack; Stark, Holger
Pharmazie, 2005 , vol. 60, # 2 p. 97 - 106
反应条件
thionyl chloride 1.) pyridine, reflux 2.) toluene; Multistep reaction;
参考文献
Supuran; Barboiu; Luca; Pop; Brewster; Dinculescu
European Journal of Medicinal Chemistry, 1996 , vol. 31, # 7-8 p. 597 - 606
反应条件
2: 48percent HBr/H2O / acetic acid View Scheme
参考文献
North Carolina State University
Patent: US2009/143230 A1, 2009 ;
Location in patent: Page/Page column 51 ;
反应条件
hydrogen bromide Yield given. Multistep reaction;
参考文献
Tolstikov, G. A.; Galin, F. Z.; Lakeev, S. N.; Khalilov, L. M.; Sultanova, V. S.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1990 , vol. 39, # 3.2 p. 535 - 541
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1990 , # 3 p. 612 - 620
反应条件
hydrogenchloride; dimethyl hydrogen phosphite; phosphorous acid trimethyl ester 1.) 80 deg C, 8 h, 2.) reflux, 20 h; Yield given. Multistep reaction;
参考文献
Ohanessian, Jacqueline; Avenel, Daniele; El Manouni, Driss; Benramdane, Mounya
Phosphorus, Sulfur and Silicon and Related Elements, 1997 , vol. 129, p. 99 - 110
反应条件
in acetonitrile 1 h; Ambient temperature;
参考文献
Anrdeichikov, Yu. S.; Zalesov, V. V.; Podushkina, N. A.
Pharmaceutical Chemistry Journal, 1980 , vol. 14, # 2 p. 99 - 104
Khimiko-Farmatsevticheskii Zhurnal, 1980 , vol. 14, # 2 p. 25 - 30
反应条件
ammonia in dichloromethane T=0 - 20°C;
参考文献
Usifoh, Cyril O.; Lambert, Didier M.; Wouters, Johan; Scriba, Gerhard K.E.
Archiv der Pharmazie, 2001 , vol. 334, # 10 p. 323 - 331
反应条件
Pd-BaSO4; xylene T=140°C; Hydrogenation;
参考文献
King; L'Ecuyer; Openshaw
Journal of the Chemical Society, 1936 , p. 352
