5-氯-3-羟甲基-1H-吲唑合成路线 （共 4 条）
反应条件
diisobutylaluminium hydride in tetrahydrofuran; toluene T=-10 - 20°C;
参考文献
The University of Tokyo; Riken; NAGANO Tetsuo; OKABE Takayoshi; KOJIMA Hirotatsu; SAITO Nae; NAKANO Hirofumi; ABE Masanao; TANAKA Akiko; HONMA Teruki; YOKOYAMA Shigeyuki; TSUGANEZAWA Keiko; YUKI Hitomi
Patent: EP2565192 A1, 2013 ;
Location in patent: Paragraph 0358 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 4 h; Heating;
参考文献
Buechi, George; Lee, Gary C. M.; Yang, David; Tannenbaum, Steven R.
Journal of the American Chemical Society, 1986 , vol. 108, # 14 p. 4115 - 4119
反应条件
1.1: sodium hydroxide / water / 1 h / 50 °C 1.2: 1 h / |Cooling with ice 1.3: 20 °C 2.1: sulfuric acid / 3 h / |Reflux 3.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / -10 - 20 °C View Scheme
参考文献
The University of Tokyo; Riken; NAGANO Tetsuo; OKABE Takayoshi; KOJIMA Hirotatsu; SAITO Nae; NAKANO Hirofumi; ABE Masanao; TANAKA Akiko; HONMA Teruki; YOKOYAMA Shigeyuki; TSUGANEZAWA Keiko; YUKI Hitomi
Patent: EP2565192 A1, 2013 ;
反应条件
pyridinium chlorochromate in dichloromethane 1 h; Heating;
参考文献
Buechi, George; Lee, Gary C. M.; Yang, David; Tannenbaum, Steven R.
Journal of the American Chemical Society, 1986 , vol. 108, # 14 p. 4115 - 4119
