2,6-二硝基-4-氟甲苯合成路线 （共 12 条）
反应条件
sulfuric acid; nitric acid T=80 - 90°C; 6 h;
参考文献
Buechi, George; Lee, Gary C. M.; Yang, David; Tannenbaum, Steven R.
Journal of the American Chemical Society, 1986 , vol. 108, # 14 p. 4115 - 4119
反应条件
sulfuric acid; nitric acid in hexane; ethyl acetate
参考文献
The Procter and Gamble Company
Patent: US5716966 A1, 1998 ;
US 5716966 A
反应条件
sulfuric acid; nitric acid in ethyl acetate
参考文献
The Procter and Gamble Company
Patent: US5916900 A1, 1999 ;
US 5916900 A
反应条件
1: Na2S*9H2O / ethanol; water / 2.5 h / 20 °C 2: acetic acid; sodium nitrite / water / 24 h / 0 - 20 °C View Scheme
参考文献
MERCK SHARP and DOHME CORP.; CERNAK, Timothy, A.; DYKSTRA, Kevin, D.; SHEN, Dong-Ming; LIU, Kun; STAMFORD, Andrew; TAN, John Qiang
Patent: WO2014/14794 A2, 2014 ;
反应条件
1: N,N-dimethyl-formamide / 5 h / 120 °C 2: hydrogen / palladium 10 on activated carbon / ethanol / 20 °C View Scheme
参考文献
MERCK SHARP and DOHME CORP.; CRESPO, Alejandro; LAN, Ping; MAL, Rudrajit; OGAWA, Anthony; SHEN, Hong; SINCLAIR, Peter J.; SUN, Zhongxiang; BUNTE, Ellen K. Vande; WU, Zhicai; LIU, Kun; DEVITA, Robert J.; SHEN, Dong-Ming; SHU, Min; TAN, John Qiang; QI, Changhe; WANG, Yuguang; BERESIS, Richard
Patent: WO2012/97744 A1, 2012 ;
WO 2012/097744 A1
反应条件
1: 57 percent / sodium / 2 h / Heating 2: 35 percent / sodium bicarbonate, sodium sulfide nonahydrate / H2O / 1 h / Heating 3: 58 percent / 1.) sodium nitrite, 12M HCl; 2.) copper(I) chloride / H2O / 0 - 5 °C / 2.) 10 min 4: 1.) pyrrolydine; 2.) H2 / 2.) 5percent palladium on charcoal / 1.) DMF, reflux, 3 h; 2.) 4 atm View Scheme
参考文献
Buechi, George; Lee, Gary C. M.; Yang, David; Tannenbaum, Steven R.
Journal of the American Chemical Society, 1986 , vol. 108, # 14 p. 4115 - 4119
反应条件
1: 57 percent / sodium / 2 h / Heating 2: 35 percent / sodium bicarbonate, sodium sulfide nonahydrate / H2O / 1 h / Heating 3: 58 percent / 1.) sodium nitrite, 12M HCl; 2.) copper(I) chloride / H2O / 0 - 5 °C / 2.) 10 min View Scheme
参考文献
Buechi, George; Lee, Gary C. M.; Yang, David; Tannenbaum, Steven R.
Journal of the American Chemical Society, 1986 , vol. 108, # 14 p. 4115 - 4119
反应条件
1: 57 percent / sodium / 2 h / Heating 2: 35 percent / sodium bicarbonate, sodium sulfide nonahydrate / H2O / 1 h / Heating View Scheme
参考文献
Buechi, George; Lee, Gary C. M.; Yang, David; Tannenbaum, Steven R.
Journal of the American Chemical Society, 1986 , vol. 108, # 14 p. 4115 - 4119
反应条件
Na2S*9H2O in ethanol; water
参考文献
GRUeNENTHAL GMBH; FRANK, Robert; BAHRENBERG, Gregor; CHRISTOPH, Thomas; SCHIENE, Klaus; DE VRY, Jean; DAMANN, Nils; FRORMANN, Sven; LESCH, Bernhard; LEE, Jeewoo; KIM, Yong-Soo; KIM, Myeong-Seop
Patent: WO2010/127855 A1, 2010 ;
Location in patent: Page/Page column 153; 154 ;
反应条件
Na2S*9H2O in ethanol; water
参考文献
The Procter and Gamble Company
Patent: US5716966 A1, 1998 ;
US 5716966 A
