1.1: hydrogen bromide / water / 72 h / 100 °C 2.1: acetyl chloride / 3.08 h / 20 - 55 °C / Inert atmosphere 3.1: ammonia / water; tert-butyl methyl ether / 0 - 20 °C 3.2: pH 2 View Scheme

1.1: hydrogen bromide / water / 72 h / 100 °C 2.1: acetyl chloride / 3.08 h / 20 - 55 °C / Inert atmosphere 3.1: ammonia / water; tert-butyl methyl ether / 0 - 20 °C 3.2: pH 2 4.1: acetone / water / 80 °C 5.1: ammonia / water / 5 h / 80 °C 5.2: 0 °C / pH 1 View Scheme

hydrogenchloride 24 h; Heating; Yield given;

1.1: hydrogen bromide / water / 72 h / 100 °C 2.1: acetyl chloride / 3.08 h / 20 - 55 °C / Inert atmosphere 3.1: ammonia / water; tert-butyl methyl ether / 0 - 20 °C 3.2: pH 2 4.1: acetone / water / 80 °C 5.1: ammonia / water / 5 h / 80 °C 5.2: 0 °C / pH 1 6.1: potassium hydroxide / water / 30 h / 0 °C 6.2: 1.17 h / 0 - 80 °C 6.3: 0.5 h / 80 - 90 °C View Scheme

1.1: hydrogen bromide / water / 72 h / 100 °C 2.1: acetyl chloride / 3.08 h / 20 - 55 °C / Inert atmosphere 3.1: ammonia / water; tert-butyl methyl ether / 0 - 20 °C 3.2: pH 2 4.1: acetone / water / 80 °C 5.1: ammonia / water / 5 h / 80 °C 5.2: 0 °C / pH 1 6.1: potassium hydroxide / water / 30 h / 0 °C 6.2: 1.17 h / 0 - 80 °C 6.3: 0.5 h / 80 - 90 °C View Scheme

1: hydrogen bromide / water / 72 h / 100 °C 2: acetyl chloride / 3.08 h / 20 - 55 °C / Inert atmosphere View Scheme

1.1: hydrogen bromide / water / 72 h / 100 °C 2.1: acetyl chloride / 3.08 h / 20 - 55 °C / Inert atmosphere 3.1: ammonia / water; tert-butyl methyl ether / 0 - 20 °C 3.2: pH 2 4.1: acetone / water / 80 °C 5.1: ammonia / water / 5 h / 80 °C 5.2: 0 °C / pH 1 6.1: potassium hydroxide / water / 30 h / 0 °C 6.2: 1.17 h / 0 - 80 °C 6.3: 0.5 h / 80 - 90 °C View Scheme