3-甲基-2-苯基-1H-吲哚合成路线 （共 60 条）
反应条件
1: With zinc trifluoromethanesulfonate
T=20°C; 1 h; Inert atmosphere;
2: With 1,1'-bis-(diphenylphosphino)ferrocene; tri-ruthenium(0)dodecacarbonyl; toluene-4-sulfonic acid in 1,4-dioxane
T=150°C; 22 h; Inert atmosphere; regioselective reaction;
参考文献
Pena-Lopez, Miguel; Neumann, Helfried; Beller, Matthias
Chemistry - A European Journal, 2014 , vol. 20, # 7 p. 1818 - 1824
反应条件
hydrogenchloride in 1,4-dioxane
T=110°C; 6 h;
参考文献
Liu, Kevin G.; Robichaud, Albert J.; Lo, Jennifer R.; Mattes, James F.; Cai, Yanxuan
Organic Letters, 2006 , vol. 8, # 25 p. 5769 - 5771
反应条件
[{(η5-C5Me5)RhCl}2(μ-Cl)2]; caesium acetate; acetic acid in 1,2-dichloro-ethane
T=100°C; 16 h; Inert atmosphere;
参考文献
Zhao, Dongbing; Shi, Zhuangzhi; Glorius, Frank
Angewandte Chemie - International Edition, 2013 , vol. 52, # 47 p. 12426 - 12429
Angew. Chem., 2013 , vol. 125, # 47 p. 12652 - 12656,4
反应条件
n-butyllithium; N,N,N',N,-tetramethylethylenediamine in tetrahydrofuran; hexane
from -78 deg C to r.t.;
参考文献
Smith, Amos B.; Visnick, Melean
Tetrahedron Letters, 1985 , vol. 26, # 32 p. 3757 - 3760
反应条件
phosphorus trichoride in benzene
Ambient temperature;
参考文献
Baccolini, Graziano; Todesco, Paolo E.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 3 p. 535 - 538
反应条件
1: 88 percent / CuI; K2CO3; N,N'-dimethylethylenediamine / molecular sieves 5 Angstroem / toluene / 24 h / 90 °C
2: 69 percent / TiCl3; Zn / 1,2-dimethoxy-ethane / 28 h / 90 °C
View Scheme
参考文献
Jones, Carrie P.; Anderson, Kevin W.; Buchwald, Stephen L.
Journal of Organic Chemistry, 2007 , vol. 72, # 21 p. 7968 - 7973
反应条件
1: 88 percent / CuI; K2CO3; N,N'-dimethylethylenediamine / molecular sieves 5 Angstroem / toluene / 24 h / 90 °C
2: 69 percent / TiCl3; Zn / 1,2-dimethoxy-ethane / 28 h / 90 °C
View Scheme
参考文献
Jones, Carrie P.; Anderson, Kevin W.; Buchwald, Stephen L.
Journal of Organic Chemistry, 2007 , vol. 72, # 21 p. 7968 - 7973
反应条件
1: NaH / dimethylformamide / 0 - 20 °C
2: CsOAc; palladium(II) complex with imidazolyl carbene ligand / N,N-dimethyl-acetamide / 24 h / 125 °C
3: tetrabutylammonium fluoride / tetrahydrofuran / 10 h / Heating
View Scheme
参考文献
Toure, B. Barry; Lane, Benjamin S.; Sames, Dalibor
Organic Letters, 2006 , vol. 8, # 10 p. 1979 - 1982
反应条件
1: AcOH / 0.5 h / 60 °C
2: HCl / dioxane / 6 h / 110 °C
View Scheme
参考文献
Liu, Kevin G.; Robichaud, Albert J.; Lo, Jennifer R.; Mattes, James F.; Cai, Yanxuan
Organic Letters, 2006 , vol. 8, # 25 p. 5769 - 5771
反应条件
1: CsOAc; palladium(II) complex with imidazolyl carbene ligand / N,N-dimethyl-acetamide / 24 h / 125 °C
2: tetrabutylammonium fluoride / tetrahydrofuran / 10 h / Heating
View Scheme
参考文献
Toure, B. Barry; Lane, Benjamin S.; Sames, Dalibor
Organic Letters, 2006 , vol. 8, # 10 p. 1979 - 1982
