3-甲基-2-苯基-1H-吲哚合成路线 （共 60 条）
反应条件
1: 1.) 2,3-dichloro-5,6-dicyan-p-benzoquinone; 2.) potassium carbonate / 1.) tetrahydrofuran, water, room temperature, 10 h; 2.) 1 h 2: 1.) potassium hydroxide / 1.) DMSO, 0.5 h; 2.) room temperature, 2 h View Scheme
参考文献
Canoira; Gonzalo Rodriguez; Subirats; Escario; Jimenez; Martinez-Fernandez
European Journal of Medicinal Chemistry, 1989 , vol. 24, # 1 p. 39 - 42
反应条件
potassium carbonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone 1.) tetrahydrofuran, water, room temperature, 10 h; 2.) 1 h; Yield given. Multistep reaction;
参考文献
Canoira; Gonzalo Rodriguez; Subirats; Escario; Jimenez; Martinez-Fernandez
European Journal of Medicinal Chemistry, 1989 , vol. 24, # 1 p. 39 - 42
反应条件
L-(+)-tartaric acid-urea melt
T=90°C; Fischer Indole Synthesis; 5 h;
参考文献
Gore, Sangram; Baskaran, Sundarababu; Koenig, Burkhard
Organic Letters, 2012 , vol. 14, # 17 p. 4568 - 4571
反应条件
potassium hydrogensulfate; silica gel
0.0666667 h; microwave irradiation;
参考文献
Kapoor, Kamal K.; Ganai, Bilal A.; Kumar, Satish; Andotra, Charanjeet S.
Synthetic Communications, 2006 , vol. 36, # 18 p. 2727 - 2735
反应条件
titanium(III) chloride; (3-cyanopropyl)dimethylsilyl chloride; zinc in ethylene glycol dimethyl ether
1 h; Heating;
参考文献
Fuerstner, Alois; Hupperts, Achim
Journal of the American Chemical Society, 1995 , vol. 117, # 16 p. 4468 - 4475
反应条件
methanol; potassium hydroxide in dichloromethane
T=25°C; 1 h;
参考文献
Stuart, David R.; Bertrand-Laperle, Megan; Burgess, Kevin M. N.; Fagnou, Keith
Journal of the American Chemical Society, 2008 , vol. 130, # 49 p. 16474 - 16475
反应条件
dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate; potassium phosphate in toluene
T=100°C; Suzuki-Miyaura coupling; 2 h;
参考文献
Fang, Yuan-Qing; Lautens, Mark
Journal of Organic Chemistry, 2008 , vol. 73, # 2 p. 538 - 549
反应条件
hydrogen; toluene-4-sulfonic acid; [rhodium(I)(carbonyl)2(acetylacetonate)] in tetrahydrofuran
T=100°C; Fischer indolization; Wagner-Meerwein rearran.; 48 h; pressure;
参考文献
Linnepe, Petra; Schmidt, Axel M.; Eilbracht, Peter
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 2 p. 302 - 313
反应条件
zinc trifluoromethanesulfonate in toluene
T=100°C;
参考文献
Kumar, Manyam Praveen; Liu, Rai-Shung
Journal of Organic Chemistry, 2006 , vol. 71, # 13 p. 4951 - 4955
反应条件
caesium acetate; diisopropylamine; palladium diacetate in N,N-dimethyl acetamide
T=125°C; 24 h;
参考文献
Wang, Xiang; Gribkov, Denis V.; Sames, Dalibor
Journal of Organic Chemistry, 2007 , vol. 72, # 4 p. 1476 - 1479
