甲基1,3-二甲基-1H-吡唑-5-羧酸酯合成路线 （共 5 条）
反应条件
1: in N,N-dimethyl-formamide T=80 - 90°C; 21 h; 2: With ammonia in water; N,N-dimethyl-formamide T=0°C; 21 h;
参考文献
PFIZER INC.
Patent: WO2006/48761 A2, 2006 ;
Location in patent: Page/Page column 33 ;
WO 2006/048761 A2
参考文献
v. Auwers; Hollmann
Chemische Berichte, 1926 , vol. 59, p. 606,1296
反应条件
methanol; sodium methylate
参考文献
Dal Monte et al.
Gazzetta Chimica Italiana, 1956 , vol. 86, p. 797,808
反应条件
1: With sodium hydroxide; water T=0 - 20°C; 18 h; 2: With hydrogenchloride in water T=0 - 20°C; 25 h; Product distribution / selectivity;
参考文献
PFIZER INC.
Patent: WO2006/48761 A2, 2006 ;
Location in patent: Page/Page column 33 ;
WO 2006/048761 A2
反应条件
1: With lithium aluminium tetrahydride in diethyl ether T=20 - 30°C; 2: With water in diethyl ether; tert-butyl methyl ether
参考文献
BASF SE
Patent: WO2009/101082 A1, 2009 ;
Location in patent: Page/Page column 71 ;
