1H-吲哚-2-基(苯基)甲酮合成路线 （共 61 条）
反应条件
1.1: n-Buli; iPr2NH / tetrahydrofuran / 0.5 h / 0 °C
1.2: 65 percent / tetrahydrofuran / -78 - 20 °C
2.1: 73 percent / 10percent NaOH / ethanol / 12 h / Heating
View Scheme
参考文献
Mahboobi, Siavosh; Teller, Steffen; Pongratz, Herwig; Hufsky, Harald; Sellmer, Andreas; Botzki, Alexander; Uecker, Andrea; Beckers, Thomas; Baasner, Silke; Schaechtele, Christoph; Ueberall, Florian; Kassack, Matthias U.; Dove, Stefan; Boehmer, Frank-D.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 5 p. 1002 - 1018
反应条件
1.1: n-Buli; iPr2NH / tetrahydrofuran / 0.5 h / 0 °C
1.2: 65 percent / tetrahydrofuran / -78 - 20 °C
2.1: 73 percent / 10percent NaOH / ethanol / 12 h / Heating
View Scheme
参考文献
Mahboobi, Siavosh; Teller, Steffen; Pongratz, Herwig; Hufsky, Harald; Sellmer, Andreas; Botzki, Alexander; Uecker, Andrea; Beckers, Thomas; Baasner, Silke; Schaechtele, Christoph; Ueberall, Florian; Kassack, Matthias U.; Dove, Stefan; Boehmer, Frank-D.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 5 p. 1002 - 1018
反应条件
1: 68 percent / Et3N / (Ph3P)2PdCl2 / 24 h / 20 °C
2: 5 percent / LiCl; K2CO3 / Pd(OAc)2 / dimethylformamide / 16 h / 100 °C
View Scheme
参考文献
Mahanty, Jyan S.; De, Mahuya; Das, Palas; Kundu, Nitya G.
Tetrahedron, 1997 , vol. 53, # 39 p. 13397 - 13418
反应条件
1: 68 percent / Et3N / (Ph3P)2PdCl2 / 24 h / 20 °C
2: 5 percent / LiCl; K2CO3 / Pd(OAc)2 / dimethylformamide / 16 h / 100 °C
View Scheme
参考文献
Mahanty, Jyan S.; De, Mahuya; Das, Palas; Kundu, Nitya G.
Tetrahedron, 1997 , vol. 53, # 39 p. 13397 - 13418
反应条件
triphenylphosphine in diphenylether
Condensation; cyclization; 2 h; Heating;
参考文献
Mali, Raghao S.; Tilve, Santosh G.; Desai, Vidya G.
Journal of Chemical Research, Miniprint, 2000 , # 1 p. 150 - 158
反应条件
1.1: thionyl chloride / chloroform / 40 °C
2.1: caesium carbonate / anhydrous xylene / 0.5 h / 20 °C
2.2: 20 °C
View Scheme
参考文献
Yang, Qing-Qing; Xiao, Cong; Lu, Liang-Qiu; An, Jing; Tan, Fen; Li, Bin-Jie; Xiao, Wen-Jing
Angewandte Chemie - International Edition, 2012 , vol. 51, # 36 p. 9137 - 9140
反应条件
potassium hydroxide in water; N,N-dimethyl-formamide
3 h; Heatingother base, other time, other temperature; Product distribution;
参考文献
Gorgos, V. I.; Zorin, L. M.; Zhungietu, G. I.; Rekhter, M. A.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983 , vol. 19, # 11 p. 1179 - 1181
Khimiya Geterotsiklicheskikh Soedinenii, 1983 , # 11 p. 1490 - 1492
反应条件
in methanol
Elimination; intramolecular ring closure; 1.5 h; Irradiation;
参考文献
Kar, Samiran; Lahiri, Saswati
Journal of the Indian Chemical Society, 1999 , vol. 76, # 11-12 p. 607 - 610
反应条件
1: 0.8 percent / NEt3
2: H2SO4 / acetic acid / 6 h / Heating
View Scheme
参考文献
Caramella, P; Corsico, A. Coda; Corsaro, A; Del Monte, D.; Albini, F. Marinone
Tetrahedron, 1982 , vol. 38, # 1 p. 173 - 182
反应条件
1: 0.8 percent / NEt3
2: H2SO4 / acetic acid / 6 h / Heating
View Scheme
参考文献
Caramella, P; Corsico, A. Coda; Corsaro, A; Del Monte, D.; Albini, F. Marinone
Tetrahedron, 1982 , vol. 38, # 1 p. 173 - 182
