(R)-α-丙烯酰基氧基-β,β-二甲基-γ-丁内酯合成路线 （共 4 条）
反应条件
hydrogenchloride; triethylamine in dichloromethane
参考文献
Chisso Corporation
Patent: US5266728 A1, 1993 ;
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane T=-10°C; 2 h;
参考文献
GILEAD SCIENCES, INC.; WATKINS, William, J.
Patent: WO2013/10112 A1, 2013 ;
Location in patent: Page/Page column 38 ;
反应条件
1: lipase from Candida cylindracea (Altus 20) / various solvent(s) / 8 h / 20 °C 2: 74 percent / Et3N / CH2Cl2 / 5 h / -24 °C View Scheme
参考文献
Haughton, Louise; Williams, Jonathan M. J.; Zimmermann, Jochen A.
Tetrahedron Asymmetry, 2000 , vol. 11, # 8 p. 1697 - 1701
反应条件
lithium hydroxide; titanium tetrachloride 1.) CH2Cl2, petroeum ether, -20 deg C, 7 days, 2.) THF, water, room temperature, 10 h; Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 61, # 24 p. 8687 - 8691
