4-(6-甲氧基苯并[d]噻唑-2-基)-N,N-二甲基苯胺合成路线 （共 12 条）
反应条件
caesium carbonate; copper(I) bromide; Pd(OAc)2*P(t-Bu)3 in N,N-dimethyl-formamide T=150°C; 1 h;
参考文献
Alagille, David; Baldwin, Ronald M.; Tamagnan, Gilles D.
Tetrahedron Letters, 2005 , vol. 46, # 8 p. 1349 - 1351
反应条件
potassium carbonate in dimethyl sulfoxide T=100°C; 16 h;
参考文献
UNIVERSITY OF PITTSBURGH
Patent: US2003/236391 A1, 2003 ;
Location in patent: Page 15 - 16 ;
反应条件
2,3-dicyano-5,6-dichloro-p-benzoquinone in dichloromethane T=20°C; 0.333333 h;
参考文献
Bose, D. Subhas; Idrees; Srikanth, Bingi
Synthesis, 2007 , # 6 p. 819 - 823
反应条件
potassium carbonate in dimethyl sulfoxide
参考文献
Klunk, William E.; Mathis JR., Chester A.; Wang, Yanming
Patent: US2002/133019 A1, 2002 ;
反应条件
potassium carbonate in dimethyl sulfoxide T=140°C; 16 h;
参考文献
Mathis, Chester A; Wang, Yanming; Holt, Daniel P; Huang, Guo-Feng; Debnath, Manik L; Klunk, William E
Journal of medicinal chemistry, 2003 , vol. 46, # 13 p. 2740 - 2754
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium carbonate in ethylene glycol dimethyl ether; water T=150°C; Suzuki coupling; Microwave irradiationCombinatorial reaction / High throughput screening (HTS);
参考文献
Auld, Douglas S.; Zhang, Ya-Qin; Southall, Noel T.; Rai, Ganesha; Landsman, Marc; MacLure, Jennifer; Langevin, Daniel; Thomas, Craig J.; Austin, Christopher P.; Inglese, James
Journal of Medicinal Chemistry, 2009 , vol. 52, # 5 p. 1450 - 1458
反应条件
Lawesson's reagent in diphenylether 3 h; Inert atmosphereHeating; regioselective reaction;
参考文献
Bose, D. Subhas; Idrees, Mohd.
Synthesis, 2010 , # 12 art. no. Z04410SS, p. 1983 - 1988
反应条件
1: triethylamine / tetrahydrofuran 2: Lawesson's reagent / toluene / Heating 3: 91 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / CH2Cl2 / 0.33 h / 20 °C View Scheme
参考文献
Bose, D. Subhas; Idrees; Srikanth, Bingi
Synthesis, 2007 , # 6 p. 819 - 823
反应条件
1: Lawesson's reagent / toluene / Heating 2: 91 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / CH2Cl2 / 0.33 h / 20 °C View Scheme
参考文献
Bose, D. Subhas; Idrees; Srikanth, Bingi
Synthesis, 2007 , # 6 p. 819 - 823
反应条件
1: triethylamine / tetrahydrofuran 2: Lawesson's reagent / toluene / Heating 3: 91 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / CH2Cl2 / 0.33 h / 20 °C View Scheme
参考文献
Bose, D. Subhas; Idrees; Srikanth, Bingi
Synthesis, 2007 , # 6 p. 819 - 823
