(S)-2,2-二甲基-1,3-二氧戊环-4-甲酸合成路线 (共 8 条)
反应条件
lithium hydroxide hydrate in methanol T=20°C; 16 h;
参考文献
BETA INNOV; CLARION, Ludovic; MERSEL, Marcel; PETITE, Didier
Patent: WO2013/168096 A1, 2013 ;
Location in patent: Page/Page column 25 ;
反应条件
phosphoric acid in ethyl acetate T=0°C; pH 2;
参考文献
Gluchowski; Bischoff; Garst; Kaplan; Dietrich; Aswad; Gaffney; Aoki; Garcia; Wheeler
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 392 - 397
反应条件
sodium hydroxide; water; penicillin acylase T=20°C; pH=7.5; 2 h; Resolution of racemateAqueous phosphate buffer;
参考文献
WO2004/3001 A1, ;
Page 10 ;
反应条件
potassium hydroxide; potassium permanganate in water T=20°C; Oxidation; 3 h;
参考文献
Tetrahedron, , vol. 55, # 30 p. 9073 - 9088
反应条件
sodium hydroxide; potassium permanganate
参考文献
Handa; Hawes; Pryce
Synthetic Communications, 1995 , vol. 25, # 18 p. 2837 - 2845
反应条件
N,N-bis-2-(hydroxyethyl)-2-amino ethane sulfonic acid; esterase from Pseudomonas fluorescens in water T=25°C; pH=7.20; Enzyme kinetics;
参考文献
Tetrahedron Asymmetry, , vol. 12, # 4 p. 545 - 556
反应条件
Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Tetrahedron Letters, , vol. 30, # 39 p. 5319 - 5322
反应条件
in diethyl ether T=0°C;
参考文献
Sodeoka, Mikiko; Sampe, Ruriko; Kagamizono, Terumi; Osada, Hiroyuki
Tetrahedron Letters, 1996 , vol. 37, # 48 p. 8775 - 8778