4-氯-7-硝基苯并-2-氧杂-1,3-二唑合成路线 （共 51 条）
反应条件
sulfuric acid; nitric acid
参考文献
Journal of Medicinal Chemistry, , vol. 11, # 2 p. 305 - 311
反应条件
1: (i) NaN3, DMSO, (ii) (heating) 2: HNO3, H2SO4 View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 11, # 2 p. 305 - 311
反应条件
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 23 °C / Inert atmosphere 2: sodium azide / dimethyl sulfoxide / 2.5 h / 23 °C / Inert atmosphere 3: sodium nitrate; sulfuric acid / water / 0.07 h / 0 °C / Inert atmosphere View Scheme
参考文献
Tetrahedron Letters, , vol. 52, # 20 p. 2533 - 2535
反应条件
potassium carbonate in tetrahydrofuran T=20°C;
参考文献
Qian, Fang; Zhang, Changli; Zhang, Yumin; He, Weijiang; Guo, Zijian; Gao, Xiang; Hu, Ping
Journal of the American Chemical Society, 2009 , vol. 131, # 4 p. 1460 - 1468
反应条件
1: sodium azide / water; acetone / 0.25 h / 20 °C / |Inert atmosphere 2: copper dichloride / water / 24 h / 80 °C / |Inert atmosphere View Scheme
参考文献
Peng, Hanjing; Dornevil, Kednerlin H.; Draganov, Alexander B.; Chen, Weixuan; Dai, Chaofeng; Nelson, William H.; Liu, Aimin; Wang, Binghe
Tetrahedron, 2013 , vol. 69, # 25 p. 5079 - 5085
反应条件
borate buffer in ethanol; water T=50°C; var. pH; Rate constant;
参考文献
Matsuoka, Hideaki; Oishi, Kanenari; Watanabe, Masaaki; Kozone, Ikuko; Saito, Mikako; Igimi, Shizunobu
Bioscience, biotechnology, and biochemistry, 2003 , vol. 67, # 11 p. 2459 - 2462
反应条件
1: sodium hydrogencarbonate / water; methanol / 1 h / 55 °C 2: hydrogenchloride / water; 1,4-dioxane / 1 h / 20 °C View Scheme
参考文献
Kuru, Erkin; Hughes, H. Velocity; Brown, Pamela J.; Hall, Edward; Tekkam, Srinivas; Cava, Felipe; De Pedro, Miguel A.; Brun, Yves V.; Vannieuwenhze, Michael S.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 50 p. 12519 - 12523
Angew. Chem., 2012 , vol. 124, # 50 p. 12687 - 12691,5
反应条件
in ethanol 2 h; Aqueous phosphate buffer;
参考文献
UNIVERSITY OF DURHAM
Patent: WO2009/34396 A2, 2009 ;
Location in patent: Page/Page column 79 ;
反应条件
sodium hydrogencarbonate in methanol T=0 - 50°C; 3.5 h;
参考文献
Novotny, Jakub; Pospechova, Katerina; Hrabalek, Alexandr; Cap, Robert; Vavrova, Katerina
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 24 p. 6975 - 6977
反应条件
sodium hydrogencarbonate in methanol T=0 - 50°C; 3.5 h;
参考文献
Novotny, Jakub; Pospechova, Katerina; Hrabalek, Alexandr; Cap, Robert; Vavrova, Katerina
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 24 p. 6975 - 6977
