potassium carbonate in N,N-dimethyl-formamide T=75°C; 20 h;

1: 1) lithium diisopropylamide / 1) THF, -78 deg C, 1 h, 2) THF, -78 deg C, 0.3 h 2: 80 percent / p-toluenesulfonic acid monohydrate, 3 Angstroem molecular sieves / toluene / 22 h / 40 °C 3: 98 percent / H2 / 10percent Pd-C / ethanol / 1 h / 25 °C / 760 Torr 4: 86 percent / K2CO3 / dimethylformamide / 20 h / 75 °C View Scheme

1: 98 percent / H2 / 10percent Pd-C / ethanol / 1 h / 25 °C / 760 Torr 2: 86 percent / K2CO3 / dimethylformamide / 20 h / 75 °C View Scheme

1: diethyl ether / 0 - 20 °C 2: K2CO3, Cs2CO3, NaI / acetone / 15 h / Heating View Scheme

1: diethyl ether / 0 - 20 °C 2: K2CO3, Cs2CO3, NaI / acetone / 15 h / Heating View Scheme

potassium carbonate; caesium carbonate; sodium iodide in acetone 15 h; Heating;

1: 43 percent / 30percent H2O2 / acetic acid / 20 h / 55 °C 2: 76 percent / benzenesulfonyl chloride / toluene / 2 h / 80 °C 3: 86 percent / K2CO3 / dimethylformamide / 20 h / 75 °C View Scheme

1: 76 percent / benzenesulfonyl chloride / toluene / 2 h / 80 °C 2: 86 percent / K2CO3 / dimethylformamide / 20 h / 75 °C View Scheme