5-(1-哌啶基)-2-吡嗪羧酸甲酯合成路线 （共 4 条）
反应条件
N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=20°C; 18 h;
参考文献
PFIZER LIMITED; COE, Jotham, Wadsworth; DEHNHARDT, Christoph, Martin; JONES, Peter; KORTUM, Steven Wade; SABNIS, Yogesh, Anil; WAKENHUT, Florian, Michel; WHITLOCK, Gavin, Alistair
Patent: WO2013/14567 A1, 2013 ;
Location in patent: Page/Page column 81 ;
WO 2013/014567 A1
参考文献
Dietz, Michel; Gruener, Sabine; Hebeisen, Paul; Meyer Reigner, Sylvie C.; Nettekoven, Matthias; Puellmann, Bernd; Roever, Stephan; Ullmer, Christoph
Patent: US2008/85905 A1, 2008 ;
Location in patent: Page/Page column 14 ;
US 20080085905 A1
反应条件
1.1: thionyl chloride / 0.5 h / -20 °C 1.2: 2 h / |Reflux 2.1: trichlorophosphate / 1.5 h / |Reflux 3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 °C View Scheme
参考文献
PFIZER LIMITED; COE, Jotham, Wadsworth; DEHNHARDT, Christoph, Martin; JONES, Peter; KORTUM, Steven Wade; SABNIS, Yogesh, Anil; WAKENHUT, Florian, Michel; WHITLOCK, Gavin, Alistair
Patent: WO2013/14567 A1, 2013 ;
WO 2013/014567 A1
反应条件
1: trichlorophosphate / 1.5 h / |Reflux 2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 °C View Scheme
参考文献
PFIZER LIMITED; COE, Jotham, Wadsworth; DEHNHARDT, Christoph, Martin; JONES, Peter; KORTUM, Steven Wade; SABNIS, Yogesh, Anil; WAKENHUT, Florian, Michel; WHITLOCK, Gavin, Alistair
Patent: WO2013/14567 A1, 2013 ;
WO 2013/014567 A1
