(1R,2R)-反式-N-Boc-1,2-环戊烷二胺合成路线 （共 4 条）
反应条件
hydrogen; palladium on activated charcoal in methanol
P=2844.31 Torr; 12 h;
参考文献
Pokorski, Jonathan K.; Witschi, Mark A.; Purnell, Bethany L.; Appella, Daniel H.
Journal of the American Chemical Society, 2004 , vol. 126, # 46 p. 15067 - 15073
反应条件
triethylamine in methanol
T=0°C; 24.25 h;
参考文献
EntreChem, S.L.; Universidad De Oviedo
Patent: EP2319825 A1, 2011 ;
Location in patent: Page/Page column 19 ;
反应条件
1.1: Et3N; ethyl chloroformate / tetrahydrofuran / 0.33 h / 0 °C
1.2: aq. NaN3 / tetrahydrofuran / 0.33 h / 0 °C
2.1: benzene / 0.5 h / Heating
3.1: CuCl / dimethylformamide / 0.75 h / 20 °C
4.1: H2 / Pd/C / methanol / 12 h / 2844.31 Torr
View Scheme
参考文献
Pokorski, Jonathan K.; Witschi, Mark A.; Purnell, Bethany L.; Appella, Daniel H.
Journal of the American Chemical Society, 2004 , vol. 126, # 46 p. 15067 - 15073
反应条件
1.1: Et3N; ethyl chloroformate / tetrahydrofuran / 0.33 h / 0 °C
1.2: aq. NaN3 / tetrahydrofuran / 0.33 h / 0 °C
2.1: benzene / 0.5 h / Heating
3.1: CuCl / dimethylformamide / 0.75 h / 20 °C
4.1: H2 / Pd/C / methanol / 12 h / 2844.31 Torr
View Scheme
参考文献
Pokorski, Jonathan K.; Witschi, Mark A.; Purnell, Bethany L.; Appella, Daniel H.
Journal of the American Chemical Society, 2004 , vol. 126, # 46 p. 15067 - 15073
